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Abstract

HLA-B35 association with nephritis in Henoch-Schönlein purpura.

Mahsa M Amoli, Wendy Thomson, Ali H Hajeer, Maria C Calviño, Carlos Garcia-Porrua, William E R Ollier and Miguel A Gonzalez-Gay
The Journal of Rheumatology May 2002, 29 (5) 948-949;
Mahsa M Amoli
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Wendy Thomson
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Ali H Hajeer
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Maria C Calviño
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Carlos Garcia-Porrua
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William E R Ollier
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Miguel A Gonzalez-Gay
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Abstract

OBJECTIVE: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. METHODS: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. RESULTS: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. CONCLUSION: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.

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The Journal of Rheumatology
Vol. 29, Issue 5
1 May 2002
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HLA-B35 association with nephritis in Henoch-Schönlein purpura.
Mahsa M Amoli, Wendy Thomson, Ali H Hajeer, Maria C Calviño, Carlos Garcia-Porrua, William E R Ollier, Miguel A Gonzalez-Gay
The Journal of Rheumatology May 2002, 29 (5) 948-949;

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HLA-B35 association with nephritis in Henoch-Schönlein purpura.
Mahsa M Amoli, Wendy Thomson, Ali H Hajeer, Maria C Calviño, Carlos Garcia-Porrua, William E R Ollier, Miguel A Gonzalez-Gay
The Journal of Rheumatology May 2002, 29 (5) 948-949;
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