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0.0435 Tw T*
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0.02921 Tw T*
(adequate justification for skipping assessments of excretion)Tj
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[(rates or for doing them badly)64.9 (. )17.8 (The proposed 2 step approach)]TJ
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(should make it possible to quantify the excretion of uric acid)Tj
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[(accurately)65 (, but only in those few patients who really need to)]TJ
0.02499 Tw T*
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[(PETER A. )-54.8 (SIMKIN,)]TJ
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(MD,)Tj
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(Adjunct Professor of Orthopaedics, )Tj
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(Department of Medicine,)Tj
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[(University of )17.7 (W)79.7 (ashington,)]TJ
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(1959 NE Pacific Street, Box 356428,)Tj
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[(Seattle, W)110.7 (A)-219.9 (98195-6428, )-17.7 (USA.)]TJ
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[(Supported in part by the T)91.8 (empleton-Piggott Bequest.)]TJ
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[(Addr)36.8 (ess r)36.8 (eprint r)36.8 (equests to Dr)110.7 (. Simkin.)]TJ
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(REFERENCES)Tj
/TT0 1 Tf
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[(1.)-875 (Moriwaki )36.9 (Y)129.2 (, )36.9 (Y)100.1 (amamoto )17.8 (T)74 (, )17.8 (T)69.8 (akahashi S, et al. Spot urine uric acid)]TJ
1.675 -1.25 Td
(to creatinine ratio used in the estimation of uric acid excretion in)Tj
T*
(primary gout. J Rheumatol 2001;28:1306-10.)Tj
-1.675 -1.25 Td
[(2.)-875 (W)79.8 (ortmann RL, Fox IH. Limited value of uric acid to creatinine)]TJ
1.675 -1.25 Td
[(ratios in estimating uric acid excretion. )54.8 (Ann Intern Med)]TJ
0 Tw T*
(1980;93:822-5.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(3.)-875.1 (Perez-Ruiz F)79.7 (,)-0.1 ( Calabozo M, )54.8 (Alonso-Ruiz )54.8 (A, Ruiz-Lucea E, Herrero-)]TJ
1.675 -1.25 Td
[(Beites )54.8 (A. )54.8 (Analysis of the methods for the classification of renal)]TJ
0 Tc T*
[(handling of urate in gout [abstract]. )54.9 (Arthritis Rheum 1997;40)]TJ
-0.00011 Tc 0 Tw T*
(Suppl:S48.)Tj
0.02499 Tw -1.675 -1.25 Td
[(4.)-875.1 (Simkin P)91.7 (A. )17.7 (T)69.7 (est of urinary excretion of uric acid [letter]. )54.8 (Ann)]TJ
0 Tc 1.675 -1.25 Td
(Intern Med 1979;91:926-7.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(5.)-875.1 (L\366f)17.7 (fler )17.7 (W)91.7 (, Simmonds HA, Gr\366bner )17.7 (W)91.7 (.)-0.1 ( Gout and uric acid)]TJ
0 Tc 1.675 -1.25 Td
(nephropathy: some new aspects in diagnosis and treatment. Klin)Tj
T*
[(W)79.8 (ochenscr 1983;61:1233-9.)]TJ
-0.00011 Tc 31.325 61.421 Td
[(6.)-875.1 (Pak CYC, Peterson R, Poindexter JR. )54.8 (Adequacy of a single stone)]TJ
0 Tc 1.675 -1.25 Td
(risk analysis in the medical evaluation of urolithiasis. J Urol)Tj
0 Tw T*
(2001;165:378-81.)Tj
0.02499 Tw -1.675 -1.25 Td
[(7.)-875 (Ricos C, Jimenez CV)128.9 (, Hernandez )54.9 (A, et al. Biological variation in)]TJ
1.675 -1.25 Td
(urine samples used for analyte measurements. Clin Chem)Tj
0 Tw T*
(1994;40:472-7.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(8.)-875.1 (Fraser CG, Harris EK. Generation and application of data on)]TJ
0 Tc 1.675 -1.25 Td
[(biological variation in clinical chemistry)64.9 (. Crit Rev Clin Lab Sci)]TJ
0 Tw T*
(1989;27:409-37.)Tj
0.02499 Tw -1.425 -1.25 Td
[(9)-875 (Wheeler LA, Sheiner LB. Clinical estimation of creatinine)]TJ
1.425 -1.25 Td
[(clearance. )54.9 (Am J Clin Pathol 1979;72:27-31.)]TJ
0.0072 Tw -2.175 -1.25 Td
[(10.)-875 (Y)100.1 (amakita )-17.8 (J, )19.1 (Y)100.1 (amamoto T)74 (,)0.1 ( )-17.7 (Moriwaki )19.1 (Y)129.2 (, T)69.8 (akahashi )-17.8 (S, T)69.8 (sutsumi )-17.7 (Z,)]TJ
0.0249 Tw 2.175 -1.25 Td
[(Hada )17.7 (T)74 (.)0.1 ( Ef)17.8 (fect of urine storage on urinary uric acid concentrations.)]TJ
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(Ann Clin Biochem 2000;37:355-9.)Tj
-0.00011 Tc -2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (Simkin P)91.7 (A, Hoover PL, Paxson CS, )17.7 (W)39.7 (ilson )17.7 (WF)79.7 (. Uric acid)]TJ
0 Tc 2.1381 -1.25 Td
(excretion: quantitative assessment from spot, midmorning serum)Tj
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[(and urine samples. )54.9 (Ann Intern Med 1979;91:44-7.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(12.)-875.1 (Boisson RC, Eynard JC, Crozier M, Grafmeyer DC. French)]TJ
0 Tc 2.175 -1.25 Td
(experience of quality assessment of quantitative urinary analysis.)Tj
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[(Clin Chim )54.9 (Acta 2000;297:285-95.)]TJ
-2.175 -1.25 Td
[(13.)-875 (Hesse )54.8 (A, Siener R, Heynck H, Jahnen )54.8 (A. )17.7 (The influence of dietary)]TJ
-0.00011 Tc 2.175 -1.25 Td
(factors on the risk of urinary stone formation. Scanning Microsc)Tj
0 Tc 0 Tw T*
[(1993;7:1)36.9 (1)36.9 (19-27.)]TJ
0.02499 Tw -2.175 -1.25 Td
[(14.)-875 (Faller J, Fox IH. Ethanol induced alterations of uric acid)]TJ
2.175 -1.25 Td
[(metabolism. )54.9 (Adv Exp Med Biol 1984;165:457-62.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(15.)-875.1 (Raivio KO, Becker MA, Meyer LJ, Greene ML, Nuki G,)]TJ
0 Tc 2.175 -1.25 Td
(Seegmiller JE. Stimulation of human purine synthesis de novo by)Tj
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(fructose infusion. Metabolism 1975;24:861-9.)Tj
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[(16.)-875.1 (Matsuura F)79.7 (,)-0.1 ( )36.8 (Y)100 (amashita S, Nakamura )17.7 (T)73.9 (,)-0.1 ( et al. Ef)17.7 (fect of visceral fat)]TJ
0 Tc 2.175 -1.25 Td
(accumulation on uric acid metabolism in male obese subjects:)Tj
T*
(visceral fat obesity is linked more closely to overproduction of uric)Tj
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[(acid than subcutaneous fat obesity)64.9 (. Metabolism 1998;47:929-33.)]TJ
-2.175 -1.25 Td
[(17.)-875 (Sahebjani H. Changes in urinary uric acid excretion in obstructive)]TJ
2.175 -1.25 Td
(sleep apnea before and after therapy with nasal continuous positive)Tj
-0.00011 Tc T*
[(airway pressure. Chest 1998;1)36.8 (13:1604-8.)]TJ
0 Tc -2.175 -1.25 Td
[(18.)-875 (Sorensen LB, Levinson DJ. Origin and extrarenal elimination of)]TJ
2.175 -1.25 Td
(uric acid in man. Nephron 1975;14:7-20.)Tj
-2.175 -1.25 Td
[(19.)-875 (Y)111.1 (u )17.7 (TF)79.8 (. Nephrolithiasis in patients with gout. Postgrad Med)]TJ
0 Tw 2.175 -1.25 Td
(1978;63:164-70.)Tj
0.02499 Tw -2.175 -1.25 Td
[(20.)-875 (Asplin JR. Uric acid stones. Semin Nephrol 1996;16:412-24.)]TJ
T*
[(21.)-875 (W)79.8 (ortmann RL. Ef)17.8 (fective management of gout: an analogy)64.9 (. )54.8 (Am J)]TJ
2.175 -1.25 Td
(Med 1998;105:513-4.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(22.)-875.1 (Stapleton FB, Nash DA. )54.8 (A)-219.9 (screening test for hyperuricosuria. )]TJ
0 Tc 2.175 -1.25 Td
(J Pediatr 1983;102:88-90.)Tj
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[(23.)-875 (Miller LA, Noe HN, Stapleton FB. Uric acid excretion in children)]TJ
2.175 -1.25 Td
[(with urolithiasis. J Pediatr 1989;1)36.9 (15:923-6.)]TJ
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