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Abstract

De novo production of IgG antinuclear antibodies in a neonate.

B G Kapogiannis, H A Gussin and M Teodorescu
The Journal of Rheumatology December 2001, 28 (12) 2744-2747;
B G Kapogiannis
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H A Gussin
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M Teodorescu
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Abstract

We describe the first case in which de novo production of multiple IgG antinuclear antibodies (ANA) occurred in a female neonate of an ANA negative mother. The infant presented at 4 weeks of age with hemorrhagic panencephalitis, diffuse intraparenchymal hemorrhages, and straight sinus thrombosis. She had been vaccinated against hepatitis B at birth. No other cause was found and maternal prenatal care was unremarkable. The infant's screening ANA test by ELISA was positive at 6 weeks with specificity for ssDNA, Sm, and nRNP/Sm. At 8 weeks antibodies to dsDNA and centromere were detected as well. By 8 months, she still had slightly elevated anti-dsDNA, Sm, and nRNP/Sm antibodies. The ANA test by immunofluorescence was abnormal at 8 weeks through 13 weeks with centromere and then homogeneous pattern. Based on similarities with other reported cases, we speculate that hepatitis B vaccination may have been involved in the development of antinuclear antibodies.

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The Journal of Rheumatology
Vol. 28, Issue 12
1 Dec 2001
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De novo production of IgG antinuclear antibodies in a neonate.
B G Kapogiannis, H A Gussin, M Teodorescu
The Journal of Rheumatology Dec 2001, 28 (12) 2744-2747;

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De novo production of IgG antinuclear antibodies in a neonate.
B G Kapogiannis, H A Gussin, M Teodorescu
The Journal of Rheumatology Dec 2001, 28 (12) 2744-2747;
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