Neuropsychiatric systemic lupus erythematosus (NPSLE) is a generic definition referring to
a series of neurological and psychiatric symptoms directly related to systemic lupus …

Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises
personalized medicine rather than the established “one size fits all” approach to drugs and …

The last decade has seen a dramatic technological revolution. The characterisation of the
majority of the common variations in our genetic code in 2003 precipitated the discovery of the …

Gene-gene and gene-environment interactions are key features in the development of
rheumatoid arthritis (RA) and other complex diseases. The aim of this study was to use and …

… Huizinga has received consultant fees (less than $10,000) from Crescendo Bioscience. Drs.
Haney, Shen, Ramanujan, Chernoff, and Ford own stock and/or stock options in Crescendo …

IL ‐10‐producing B cells have a regulatory effect in various mouse models for immune‐mediated
disorders via secretion of IL ‐10, a potent immunoregulatory cytokine. However, …

Genetic factors associated with rheumatoid arthritis (RA) might involve variant tumour
necrosis factor (TNF)-alpha genes. Therefore, polymorphisms at positions -308, -238, -376, -163 …

Objectives To determine the safety, tolerability and signs of efficacy of MOR103, a human
monoclonal antibody to granulocyte–macrophage colony-stimulating factor (GM-CSF), in …

FcRIII (the CD16-antigen), a low affinity receptor for IgG, is expressed by neutrophils, natural
killer lymphocytes, and macrophages. We have developed a sensitive radioimmunoassay …

Neutrophils express two distinct types of receptor for the Fc region of IgG, FcRII and FcRIII, in
amounts of 10,000 to 20,000 FcRII (40 Kd) and 100,000 to 200,000 FcRIII (50 to 80 Kd) per …