[HTML][HTML] NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
JA Roman-Blas, SA Jimenez - Osteoarthritis and cartilage, 2006 - Elsevier
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response. …
regulation of expression of numerous genes in the setting of the inflammatory response. …
[HTML][HTML] Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
S Piera-Velazquez, Z Li, SA Jimenez - The American journal of pathology, 2011 - Elsevier
The accumulation of a large number of myofibroblasts is responsible for exaggerated and
uncontrolled production of extracellular matrix during the development and progression of …
uncontrolled production of extracellular matrix during the development and progression of …
Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis
SA Jimenez, CT Derk - Annals of internal medicine, 2004 - acpjournals.org
This review discusses the clinical and physiologic principles of systemic sclerosis, a disease
of unknown origin characterized by excessive deposition of collagen and other connective …
of unknown origin characterized by excessive deposition of collagen and other connective …
[HTML][HTML] Osteoarthritis cartilage histopathology: grading and staging
KPH Pritzker, S Gay, SA Jimenez, K Ostergaard… - Osteoarthritis and …, 2006 - Elsevier
OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties
in their utility for early disease, as well as their reproducibility and validity. Our objective …
in their utility for early disease, as well as their reproducibility and validity. Our objective …
Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human …
J Varga, J Rosenbloom, SA Jimenez - Biochemical Journal, 1987 - portlandpress.com
It has been previously shown that transforming growth factor beta (TGF beta) is capable of
stimulating fibroblast collagen and fibronectin biosynthesis. The purpose of this study was to …
stimulating fibroblast collagen and fibronectin biosynthesis. The purpose of this study was to …
[HTML][HTML] Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis
CM Artlett, JB Smith, SA Jimenez - New England Journal of …, 1998 - Mass Medical Soc
Background Systemic sclerosis is a disease of unknown origin which often occurs in women
after their childbearing years. It has many clinical and histopathological similarities to …
after their childbearing years. It has many clinical and histopathological similarities to …
A disease severity scale for systemic sclerosis: development and testing.
…, S Jablonska, MI Jayson, SA Jimenez… - The Journal of …, 1999 - europepmc.org
Objective To develop and test a severity scale for individual organ involvements in systemic
sclerosis (SSc, scleroderma). Methods An international study group completed the following …
sclerosis (SSc, scleroderma). Methods An international study group completed the following …
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs
…, A Witkiewicz, A Rostami, SA Jimenez… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs
in animal genomes remains a vexing question. Here, we report findings from analyzing …
in animal genomes remains a vexing question. Here, we report findings from analyzing …
Selective inhibition of human diploid fibroblast collagen synthesis by interferons.
SA Jimenez, B Freundlich… - The Journal of clinical …, 1984 - Am Soc Clin Investig
The effects of alpha- and gamma-interferons (IFNs) on collagen production by confluent
human diploid fibroblasts in culture were examined. It was found that partially purified alpha-…
human diploid fibroblasts in culture were examined. It was found that partially purified alpha-…
Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases
S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …