Background Cyclophosphamide and glucocorticoids have been the cornerstone of
remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)−associated …

Background The 18-month efficacy of a single course of rituximab as compared with conventional
immunosuppression with cyclophosphamide followed by azathioprine in patients with …

Background Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the
prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin…

… between the BVAS/WG and the PGA was r = 0.81 (95% confidence interval 0.73–0.87). … r
= 0.93 for the BVAS/WG and r = 0.88 for the PGA in the first and r = 0.91 for the BVAS/WG and r …

Objective To reevaluate the efficacy and safety of adjunctive low‐dose methotrexate (MTX)
in giant cell arteritis (GCA). Methods An individual patient data meta‐analysis of 3 …

Background More than half of patients with polymyalgia rheumatica have a relapse during
tapering of glucocorticoid therapy. Previous studies have suggested that interleukin-6 …

BACKGROUND. TGF-β has potent profibrotic activity in vitro and has long been implicated
in systemic sclerosis (SSc), as expression of TGF-β–regulated genes is increased in the skin …

… Patients were excluded if they had active infectious or neoplastic disease, concomitant
connective tissue disease, prior immu nosupp re ss ive therapy within the past year, and co-morbid …

BACKGROUND: The pathogenic significance of antineutrophilic cytoplasmic antibodies (ANCA)
in Wegener’s granulomatosis is controversial. Their presence is influenced by the extent…

Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant cell
arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or relapsing …