Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
…, JL Nelson, SK Agarwal, S Assassi, P Gourh… - Nature …, 2010 - nature.com
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and
internal organs that leads to profound disability and premature death. To identify new SSc …
internal organs that leads to profound disability and premature death. To identify new SSc …
[HTML][HTML] Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
…, J Varga, M Hinchcliff, AT Lee, P Gourh… - PLoS …, 2011 - journals.plos.org
The aim of this study was to determine, through a genome-wide association study (GWAS),
the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis …
the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis …
Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients
FK Tan, X Zhou, MD Mayes, P Gourh, X Guo… - …, 2006 - academic.oup.com
Objective. To obtain a global view of the immunological alterations occurring in early systemic
sclerosis (SSc) by transcriptional profiling of peripheral blood cells (PBCs). Methods. …
sclerosis (SSc) by transcriptional profiling of peripheral blood cells (PBCs). Methods. …
Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 …
FC Arnett, P Gourh, S Shete, CW Ahn… - Annals of the …, 2010 - ard.bmj.com
… % CI for p values <0.017, which accounts for the Bonferroni corrections by the number of
comparisons for each HLA genotype (0.017 = 0.05/3). LD coefficients and the corresponding p …
comparisons for each HLA genotype (0.017 = 0.05/3). LD coefficients and the corresponding p …
Systemic sclerosis and lupus: points in an interferon‐mediated continuum
…, MD Mayes, FC Arnett, P Gourh… - … : Official Journal of …, 2010 - Wiley Online Library
… The difference in IFN score among all 3 groups was statistically significant (P < 0.001 for all
… correlated with the higher IFN scores (P = 0.005, P = 0.001, and P = 0.004, respectively); a …
… correlated with the higher IFN scores (P = 0.005, P = 0.001, and P = 0.004, respectively); a …
[HTML][HTML] Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
P Gourh, FC Arnett, S Assassi, FK Tan, M Huang… - Arthritis research & …, 2009 - Springer
… with a disease duration of 0 to 5 years (P < 0.0001 and P < 0.0001, respectively) and a
duration of 5 to 10 years (P < 0.0001 and P = 0.007, respectively) compared with controls (Figure …
duration of 5 to 10 years (P < 0.0001 and P = 0.007, respectively) compared with controls (Figure …
Clinical and genetic factors predictive of mortality in early systemic sclerosis
…, JD Reveille, A Karnavas, P Gourh… - Arthritis Care & …, 2009 - Wiley Online Library
… variable with mortality (P = 0.692 for African Americans, P = 0.349 for Hispanics, P = 0.564
for … The P values for our overall final models with and without the HLA genes were both less …
for … The P values for our overall final models with and without the HLA genes were both less …
Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
P Gourh, SK Agarwal, E Martin, D Divecha… - Journal of …, 2010 - Elsevier
OBJECTIVE: Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that
clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, …
clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, …
Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients
… was associated with lower alkaline phosphatase levels (p = 0.001). Even after … (p = 0.051
and p = 0.003), while anti-RNAP was associated with lower alkaline phosphatase values (p = …
and p = 0.003), while anti-RNAP was associated with lower alkaline phosphatase values (p = …
BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians
B Rueda, P Gourh, J Broen, SK Agarwal… - Annals of the …, 2010 - ard.bmj.com
Objective To investigate the possible association of the BANK1 gene with genetic susceptibility
to systemic sclerosis (SSc) and its subphenotypes. Methods A large multicentre case–…
to systemic sclerosis (SSc) and its subphenotypes. Methods A large multicentre case–…