There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic …

Objective To review systematically the evidence for an effect of long chain and shorter chain
omega 3 fatty acids on total mortality, cardiovascular events, and cancer. Data sources …

There is abundant evidence that the risk of atherosclerotic vascular disease is directly related
to plasma cholesterol levels. Accordingly, all of the national and transnational screening …

Background Type 2 diabetes is associated with a substantially increased risk of cardiovascular
disease, but the role of lipid-lowering therapy with statins for the primary prevention of …

… Durrington, Robert Fagard, Simona Giampaoli, Harry Hemingway, Jan Hakansson,
Sverre Erik Kjeldsen, Mogens Lytken Larsen, Giuseppe Mancia, Athanasios J. Manolis …

Oxidative modification of low‐density lipoprotein (LDL) enhances its uptake by macrophages
in tissue culture and in vivo may underly the formation of arterial fatty streaks, the …

We have investigated the Cu 2+ induced generation of lipid peroxides in low density lipoprotein
(LDL) incubated with high density lipoprotein (HDL) and with purified paraoxonase, an …

The lipodystrophies are a group of disorders characterized by the absence or reduction of
subcutaneous adipose tissue. Partial lipodystrophy (PLD; MIM 151660) is an inherited …

The activity of serum paraoxonase, an enzyme located on high-density lipoprotein, has
been investigated in familial hypercholesterolaemia (FH) and insulin dependent diabetes …

Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation
of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic …