Updates on T helper type 17 immunity in respiratory disease

N Iwanaga, JK Kolls - Immunology, 2019 - Wiley Online Library
Interleukin‐17 ( IL ‐17)‐producing cells play a critical role in mucosal immunity including the
respiratory tract. This review will highlight recent advances in our understanding of these …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

…, C Wang, H Yang, J Mudd, JM Currey, N Iwanaga… - Theranostics, 2021 - ncbi.nlm.nih.gov
… To examine SARS-CoV-2 infection in tissues of K18 mice, we used qRT-PCR to quantify
the nucleocapsid (N) sub-genomic viral RNA, a correlate of active virus replication 33 , 34 , in …

RS3PE syndrome presenting as vascular endothelial growth factor associated disorder

K Arima, T Origuchi, M Tamai, N Iwanaga… - Annals of the …, 2005 - ard.bmj.com
Objectives: To characterise serum concentrations of various cytokines and detection by
magnetic resonance imaging (MRI) of synovial hypervascularity in patients with remitting …

The integrin binding peptide, ATN-161, as a novel therapy for SARS-CoV-2 infection

BJ Beddingfield, N Iwanaga, PP Chapagain… - Basic to Translational …, 2021 - jacc.org
Many efforts to design and screen therapeutics for the current severe acute respiratory
syndrome-coronavirus-2 (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry …

Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell line.

…, M Tamai, H Nakamura, N Iwanaga… - The Journal of …, 2007 - jrheum.org
OBJECTIVE: We investigated expression of toll-like receptor (TLR) in labial salivary glands
of patients with Sjögren's syndrome (SS) and functional TLR expression in the cultured …

Beta-blockers and fetal growth restriction in pregnant women with cardiovascular disease

…, M Sawada, M Tsuritani, M Yoshida, N Iwanaga… - Circulation …, 2016 - jstage.jst.go.jp
Background: The effects of β-adrenergic blockers on the fetus are not well understood. We
analyzed the maternal and neonatal outcomes of β-adrenergic blocker treatment during …

Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection

K Han, RV Blair, N Iwanaga, F Liu… - American journal of …, 2021 - atsjournals.org
… A28527; Thermo Fisher) and a premix of forward and reverse primers and a FAM-labeled
probe targeting the N1 amplicon of N gene (2019-nCoV RUO Kit, Cat. No. 10006713; IDT-DNA…

Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan

…, N Iwanaga, S Ide, T Mihara, N Hosogaya… - Antimicrobial agents …, 2012 - Am Soc Microbiol
We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A.
fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) …

[HTML][HTML] Familial Mediterranean fever is no longer a rare disease in Japan

K Migita, Y Izumi, Y Jiuchi, N Iwanaga… - Arthritis research & …, 2016 - Springer
Background The aim of this study was to evaluate the clinical manifestations and prevalence
of familial Mediterranean fever (FMF) in Japanese patients with unexplained fever and …

Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling

N Iwanaga, K Chen, H Yang, S Lu, JP Hoffmann… - Science …, 2021 - science.org
… (B) C57BL/6 mice immunized and challenged as in (A) were sacrificed, and bacterial burden
(CFU) in lungs and spleen was determined at 24 hours after infection (n = 7 to 10, ****P < …