Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

… In 1989, Ferrara and Henzel (61) reported the isolation of a diffusible endothelial cell-specific
mitogen from medium conditioned by bovine pituitary follicular cells, which they named “…

… Such effects appear to be caused by a decrease in venous return, mediated primarily by
endothelial cell-derived nitric oxide, as assessed by the requirement for an intact …

THE development of new blood vessels (angiogenesis) is required for many physiological
processes including embryogenesis, wound healing and corpus luteum formation 1,2 . Blood …

ANGIOGENESIS is required for a wide variety of physiological and pathological processes
1 . The endothelial cell-specific mitogen vascular endothelial growth factor (VEGF) 2,3 is a …

… The presence of a potential Nlinked glycosylation site (17) at Asn74 suggests that VEGF is
a glycoprotein. Clusters of basic amino acids present at the positions around 110, 123, and …

Hypertrophic chondrocytes in the epiphyseal growth plate express the angiogenic protein
vascular endothelial growth factor (VEGF). To determine the role of VEGF in endochondral …

A growth factor for vascular endothelial cells was identified in the media conditioned by
bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium …

Background Bevacizumab, a monoclonal antibody against vascular endothelial growth factor,
has shown promising preclinical and clinical activity against metastatic colorectal cancer, …

Background Retinal ischemia induces intraocular neovascularization, which often leads to
glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the …