Dendritic cells: immunological sentinels with a central role in health and disease

LH Stockwin, D McGONAGLE… - Immunology and cell …, 2000 - Wiley Online Library
Dendritic cells: Immunological sentinels with a central role in health and disease - Stockwin -
2000 - Immunology & Cell Biology - Wiley Online Library … Luke H Stockwin … Luke H Stockwin

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

LH Stockwin, SX Yu, S Borgel… - … journal of cancer, 2010 - Wiley Online Library
The “Warburg effect,” also termed aerobic glycolysis, describes the increased reliance of
cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, …

Antibodies as therapeutic agents: vive la renaissance!

LH Stockwin, S Holmes - Expert opinion on biological therapy, 2003 - Taylor & Francis
Until recently, the concept of antibodies as in vivo therapeutics was still considered to be an
exceedingly ambitious goal. However, in 2003, the situation has been completely …

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

CN Hancock, LH Stockwin, B Han, RD Divelbiss… - Free Radical Biology …, 2011 - Elsevier
In this study, a Cu 2+ chelate of the novel thiosemicarbazone NSC 689534 was evaluated
for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low …

[HTML][HTML] Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal …

…, L Probst, BS Lee, K Pulford, AH Banham, L Stockwin… - Molecular cancer, 2006 - Springer
… or L, we observed essentially quantitative translocation of S into paraspeckles, apparently
indistinguishable from those of XL or L alone (Figure 7). Nuclear localization of the XL/S or L/S …

The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response

TG Glaros, LH Stockwin, ME Mullendore… - Cancer chemotherapy …, 2012 - Springer
Purpose To establish whether NSC80467, a novel fused naphthquinone imidazolium, has a
similar spectrum of activity to the well-characterized “survivin suppressant” YM155 and to …

Artemisinin dimer anticancer activity correlates with heme‐catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

LH Stockwin, B Han, SX Yu… - … Journal of Cancer, 2009 - Wiley Online Library
Analogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anticancer
activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to …

[HTML][HTML] Gene expression profiling of alveolar soft-part sarcoma (ASPS)

LH Stockwin, DT Vistica, S Kenney, DS Schrump… - BMC cancer, 2009 - Springer
Background Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft
tissue sarcoma affecting predominantly adolescents and young adults. In an attempt to gain …

Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class I-independent uptake of recombinant adenoviruses into …

D McDonald, L Stockwin, T Matzow, ME Zajdel… - Gene therapy, 1999 - nature.com
The role of two receptors, previously proposed to mediate the entry of adenoviruses into
human cells, the coxsackie and adenovirus receptor (CAR) and the major histocompatibility …

The role of therapeutic antibodies in drug discovery

LH Stockwin, S Holmes - Biochemical Society Transactions, 2003 - portlandpress.com
The last 5 years have seen a major upturn in the fortune of therapeutic monoclonal antibodies
(mAbs), with nine mAbs approved for clinical use during this period and more than 70 now …