Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug‐metabolizing
enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive …

The isoenzymes which catalyse the polymorphic hydroxylations of debrisoquine/sparteine
and S-mephenytoin are cytochromes P450 2D6 and P450 2C19 (CYP2D6 and CYP2C19), …

… at plasma concentrations of 15 to 40 µmol/L and a similar optimal plasma concentration range
… -life of unchanged epoxide was 6.1 hours with a mean volume of distribution of 0.74 L/kg. …

… /L magnesium dichloride, 0.2-mmol/L deoxyribonucleoside triphosphates, and 0.4-μmol/L …
of 1.5-mmol/L MgCl 2 being used for the wild-type reaction, 2.5-mmol/L MgCl 2 being used …

… of CSF concentrations of 5-HIAA, which probably reflects drug action on central serotonin
neurons, was maximal at a plasma clomipramine concentration of about 300 nmole/L. At …

… attempts was 68.5 nmole/L (SD, 12.8 nmole/L) and 97.4 nmole/L (SD, 27.0 nmole/L) in the
14 … Bertilsson L, Palmer L: Determination of isomeric acid dopamine metabolites by mass …

… The 5-HIAA concentration in the CSF was measured according to Bertilsson et al. (8).
The distribution of 5-HIAA in sample 2 was similar to that previously found in sample 1 (Fig. …

… The median MR did not differ between subjects homozygous for the wt allele, heterozygous
individuals (L/wt) or homozygous for the -L allele (Table 2), indicating the expression of an …

Objective Because treatment with tumor necrosis factor (TNF) antagonists may increase the
risk of tuberculosis (TB), and because knowledge of the risk of TB in rheumatoid arthritis (RA…

… This is supported by the IR spectra of fresh APTES on gold and aluminum oxide which
had shoulders at frequencies less than I 1 l0 cm-l, indicating a small amount of siloxane and/or …