Objectives To investigate the possibility of discontinuing adalimumab (ADA) for 1 year
without flaring (DAS28-erythrocyte sedimentation rate (ESR) ≥3.2), and to identify factors …

A major neurotransmitter dopamine transmits signals via five different seven-transmembrane
G protein-coupled receptors termed D1–D5. Several studies have shown that dopamine …

Objective To elucidate the diversity of systemic lupus erythematosus (SLE) based on
immunophenotyping. Methods Peripheral blood mononuclear cells were obtained from 143 SLE …

… Yunoue 4 K. Saito The First Department of Internal Medicine, School of Medicine, University
of … Nakamura I, Omata Y, Naito M, Ito K. Blockade of interleukin 6 signaling induces marked …

It is often difficult to manage refractory gastrointestinal tract complications of Behçet’s
disease (entero-BD) by conventional therapy. In this study, we assessed the short- and long-term …

Objectives. To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical
practice. Methods. We observed 232 consecutive RA patients who began tocilizumab in …

Objective We examined the efficacy and safety of rituximab in patients with refractory
systemic lupus erythematosus (SLE). Methods The study enrolled 63 SLE patients who were …

Helicobacter pylori infects the stomachs of nearly a half the human population, yet most
infected individuals remain asymptomatic, which suggests that there is a host defense against …

Background Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD)
is a life-threatening condition. Serum cytokine levels are potentially suitable …

Objective. Rituximab has recently emerged as a novel treatment strategy for systemic lupus
erythematosus (SLE). We investigated longitudinally the differentiation and phenotypic …