Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus
(SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE …

… Latinis has received consulting fees and speaking fees from Human Genome Sciences, Inc.
… Latinis has received consulting fees and speaking fees from Human Genome Sciences, Inc. …

The EXPLORER study was designed to assess the response to rituximab versus placebo in
patients with moderate to severe extrarenal systemic lupus erythematosus (SLE) receiving …

Antigen receptor engagement on T lymphocytes activates transcription factors important for
stimulating cytokine gene expression. This is critical for clonal expansion of antigen-specific …

T lymphocytes undergo apoptosis in response to a variety of stimuli, including exposure to
UV radiation and γ-irradiation. While the mechanism by which stress stimuli induce apoptosis …

… LATINIS, SUSAN MANZI, W. JOSEPH McCUNE, DANA TEGZOVÁ, JAMES D. McKAY, …
Wallace and Latinis have received consulting fees, speaking fees, and/or honoraria from HGS …

Stimulation of mature peripheral T cells by TCR engagement results in activation of signals
that drive induction of cytokine gene expression and clonal expansion. However, under some …

Stimulation through the Fas/APO-1 receptor results in apoptosis through an incompletely
characterized signaling pathway. More is known regarding signal transduction events that …

INTRODUCTION PTK (6–9). Interestingly, however, unlike growth factor receptors (such as
the epidermal growth factor re-StimulationofTlymphocytesviatheirantigenrecep-ceptor or …

We provide the basics for the clinician who might be called on to consider the diagnosis of
diseases such as systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) in their …