The entire coding sequence of the p53 gene was analysed for the presence of mutations in
12 families conforming to a restricted definition of Li-Fraumeni syndrome (classic LFS) and …

We have previously reported on the analysis of TP53 coding mutations in 12 classic Li-Fraumeni
syndrome (LFS) families plus 9 families that were Li-Fraumeni-like (LFL) families (JM …

The Li–Fraumeni cancer predisposition syndrome is associated with germline TP53
mutations in the majority of families. We have investigated cancer incidence in 34 Li–Fraumeni …

We have studied a total of 36 tumours from 28 patients with germline mutations to the TP53
gene for loss of heterozygosity at TP53 using techniques of both direct sequencing and …

We present an extended family with Li-Fraumeni syndrome characterised by gastric and
breast carcinoma, glioma, sarcoma, and leukaemia. This family showed strong evidence of …

OBJECTIVE: Patients with rheumatoid arthritis (RA) with lower socioeconomic status (SES)
are known to have more severe disease, more comorbidity, and higher mortality. It is not …

We report an extensive Li–Fraumeni-like family in which there is an unusual spectrum of
tumours at relatively late onset. A germline TP53 splice donor mutation in exon 4 is present in …

We report a family with the Li-Fraumeni syndrome (LFS) in whom we have been unable to
detect a mutation in the coding sequence of the p53 gene. Analysis of linkage to three …

We report a Li-Fraumeni syndrome family in which we have detected a splice acceptor
mutation in intron 3 of TP53. The mutation affects one of the invariant residues at the splice …

… (54) A preliminary technoeconomic analysis (S6) shows that ammonia could be produced
at 10 3 kg yr –1 with a solar energy consumption of 10 4 kJ mol N –1 (assuming 20% solar …