Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | NEJM Skip to main content
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Rheumatoid arthritis, juvenile idiopathic arthritis, the seronegative spondyloarthropathies
including psoriatic arthritis, and systemic lupus erythematosus are all examples of rheumatic …

Rheumatoid arthritis (RA) is characterised by the presence of an inflammatory synovitis
accompanied by destruction of joint cartilage and bone. Destruction of cartilage matrix results …

Considerable progress has been made in identifying the transcription factors involved in the
early specification of the B-lymphocyte lineage. However, little is known about factors that …

… Gravallese’s work was supported by a grant from Pfizer, Inc. and by the Scholars in …
Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types …

There is considerable evidence that osteoclasts are involved in the pathogenesis of focal bone
erosion in rheumatoid arthritis. Tumor necrosis factor-related activation-induced cytokine, …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

… Tissue Preparation Fixed and decalcified synovial tissues for paraffin embedding were
washed in graded ethanol solutions and stored overnight at 40C in 100% ethanol. Samples were …

Nuclear factor of activated T cells (NF-AT) is the name of a family of four related transcription
factors that may be needed for cytokine gene expression in activated lymphocytes 1 , 2 , 3 , …

… Gravallese has received salary support from the New England Journal of Medicine (more
than $10,000). Dr. Mikuls has received consulting fees, speaking fees, and/or honoraria from …