Objective We undertook a 2‐part, phase I, double‐blind, placebo‐controlled study to evaluate
the safety and pharmacokinetics of multiple intravenous infusions of sirukumab, a human …

… The physiological and pathological role of IL-6 has been illustrated in many in vitro and in
vivo studies collectively suggesting that IL-6 induces the differentiation of B cells into antibody-…

… proportion of subjects in each treatment group mounted an effective 2-fold increase in titers
to polyvalent pneumococcal vaccine, indicating that IV infliximab did not interfere with B cell-…

… The average peak decrease in CCL17 levels occurred within 4 weeks of dosing and
gradually returned to baseline levels through study end at 16 weeks postdosing (Figure 2B). …

Aims To assess the pharmacokinetics (PK) and pharmacodynamics (PD) of infliximab (INFX)
prepared in a new highly concentrated formulation following single subcutaneous (SC) …

Aim To establish if there are psychometrically sound standardized tests or test items to assess
handwriting readiness in 5‐ and 6‐year‐old children on the levels of occupations activities/…

The development of a homologous transformation system for Aspergillus niger is described.
The system is based on the use of an orotidine-5′-phosphate decarboxylase deficient …

Aim: Informal caregivers share common experiences in providing care to someone with
health and/or social needs, but at the same time their experiences differ across diverse …

Phytase catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol
and inorganic phosphate. A gene (phyA) of Aspergillus niger NRRL3135 coding for …

… Robben, de Rooij, Kröse, van Hartingsveldt, de Vos: critical revision of manuscript for
important intellectual content. All authors read and approved the final manuscript. …