B cell abnormalities contribute to the development and progress of autoimmune disease.Traditionally,
the role of B cells in autoimmune disease was thought to be predominantly limited …

B cells regulate immune responses by producing antigen-specific antibodies 1 . However,
specific B-cell subsets can also negatively regulate T-cell immune responses, and have been …

Systemic sclerosis (SSc) is a collagen disease characterized by autoimmunity and excessive
extracellular matrix deposition in the skin and visceral organs. Although the pathogenic …

Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the
various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and …

Background: The signal transducer and activator of transcription 3 (STAT3) is a key signalling
molecule implicated in the regulation of growth and malignant transformation. Constitutive …

Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and
CLL cells share multiple phenotypic markers with regulatory B cells that are competent to …

B cells mediate multiple functions that influence immune and inflammatory responses. In
mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate …

Objective Rapamycin, a novel macrolide immunosuppressive drug, is increasingly used as
an agent for posttransplant immunosuppression and treatment of autoimmune disease. The …

To determine serum interleukin-33 (IL-33) levels and their associations with clinical parameters
in patients with systemic sclerosis (SSc). Serum IL-33 levels were examined by enzyme-…

Background Systemic sclerosis is a connective tissue disease characterised by multiorgan
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …