A functional single nucleotide polymorphism, 1858C> T, in the PTPN22 gene, encoding a
tyrosine phosphatase, has been reported to be associated with type I diabetes and some other …

OBJECTIVE: To describe the physical and psychosocial outcome in patients with juvenile
rheumatoid arthritis (JRA), compared with subjects in the general population, and to determine …

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders. Although the
pathogenesis is not completely understood, many studies point to a genetic component in the …

Objective To assess the frequency of sacroiliitis and the radiographic and clinical outcome
in juvenile idiopathic arthritis (JIA) and determine patient characteristics, early disease …

Notch receptors are determinants of cell fate decisions. To define the role of Notch in the
adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD…

Gremlin is a glycoprotein that binds bone morphogenetic proteins (BMPs) 2, 4, and 7,
antagonizing their actions. Gremlin opposes BMP effects on osteoblastic differentiation and …

HLA class II alleles were determined by PCR‐SSO and PCR‐SSP typing of DNA samples
from 55 Nentsy, 81 Saami and 73 Pomor individuals from the North‐European part of Russia. …

Background: Juvenile idiopathic arthritis (JIA) is strongly associated with the DR8-DQ4
haplotype. The genes encoding DR8 and DQ4 are in strong linkage disequilibrium (LD) and …

Objective and Design: To examine whether ligation of the adhesive receptors - selectin L
and Mac-1 on the neutrophil surface could induce gelatinase B exocytosis.¶Materials: …

Objective. To compare outcomes in patients with juvenile psoriatic arthritis (PsA) with those
in patients with other juvenile idiopathic arthritis (JIA) subtypes, and to evaluate …