Therapeutic proteins are proteins engineered in the laboratory for pharmaceutical use.
Although they tend to offer a better safety margin than most synthetic small molecules because …

The dynamic onset of DNA fragmentation in mammalian sperm populations varies widely in
different species when the spermatozoa are incubated in vitro at body temperature for …

At the sequence level, genetic diversity is provided by de novo transmittable mutations that
may act as a substrate for natural selection. The gametogenesis process itself is considered …

Background The last international consensus on the management of type 2 diabetes (T2D)
recommends SGLT-2 inhibitors or GLP-1 agonists for patients with clinical cardiovascular (CV…

Purpose Most drugs are excreted in maternal milk and may therefore be ingested by children
during breastfeeding. Data concerning the safety of the use of drugs by breastfeeding …

The aim of this retrospective cohort study was to investigate the incidence of delayed
methotrexate elimination in patients treated with high‐dose methotrexate (≥1 g/m 2 ) for …

Purpose The aim of this study is to assess international guidelines implementation concerning
thromboprophylaxis strategy in myeloma patients treated with immunomodulatory drugs. …

Aims The risk of hypoglycaemia with tramadol ( TRM ) is not well described. Our aim was to
analyze spontaneous reports of hypoglycaemia registered in the F rench Pharmacovigilance …

Proton pump inhibitors (PPIs) are widely used drugs in the treatment or prophylaxis of peptic
ulcer and gastro-oesophageal reflux disease. In addition to their well documented efficacy, …

Phases I and II of the WINNER project contributed to the development, integration, and
assessment of new mobile network techniques from 2004 to 2007. Some of these techniques are …