Purpose: The aim of this study was to conduct a systematic review, and where possible meta-analyses,
of molecular and biological tumor markers described in neuroblastoma, and to …

Objective The Health Assessment Questionnaire is widely used for patients with inflammatory
polyarthritis (IP) and its subset, rheumatoid arthritis (RA). In this study, we evaluated the …

Objectives. To systematically review and meta-analyse evidence on the effectiveness of the
TNF-α inhibitors when used sequentially. Methods. Systematic review of comparative and …

Background Optimum surgical intervention for low-grade haemorrhoids is unknown. Haemorrhoidal
artery ligation (HAL) has been proposed as an efficacious, safe therapy while rubber …

Economic evaluation conducted in terms of cost per quality-adjusted life-year (QALY) provides
information that decision makers find useful in many parts of the world. Ideally, clinical …

Objectives Health utility data generated by using the EuroQol five-dimensional (EQ-5D)
questionnaire are right bounded at 1 with a substantial gap to the next set of observations, left …

Background We investigate methods used to analyse the results of clinical trials with survival
outcomes in which some patients switch from their allocated treatment to another trial …

A source of debate in the field of health care priority setting is whether health gains should be
weighted differently for different groups of patients. The debate has recently focused on the …

Estimates of the overall survival benefit of new cancer treatments are often confounded by
treatment switching in randomised controlled trials (RCTs) – whereby patients randomised to …

Background. Treatment switching commonly occurs in clinical trials of novel interventions in
the advanced or metastatic cancer setting. However, methods to adjust for switching have …