Since the characterization of CD4 + CD25 + regulatory T (Treg) cells in mice, significant
progress has been made in the definitions of the phenotype and the function of human Treg cells …

Systemic lupus erythematosus (SLE) is uncommon after the age of 50 years, and studies of
elderly patients with SLE are scarce. We conducted the current study to analyze …

While our knowledge of the pathogenesis of Takayasu's arteritis (TA) has considerably
improved during the last decade, the exact pathogenic sequence remains to be elucidated. It is …

FoxP3 is a key transcription factor for the development and function of natural CD4 + regulatory
T cells (Treg cells). Here we show that human FoxP3 + CD4 + T cells were composed of …

Humoral immune responses are typically characterized by primary IgM antibody responses
followed by secondary antibody responses associated with immune memory and composed …

Tangier disease (TD) was first discovered nearly 40 years ago in two siblings living on Tangier
Island 1. This autosomal co-dominant condition is characterized in the homozygous state …

Objectives To develop recommendations for the management of adult and paediatric lupus
nephritis (LN). Methods The available evidence was systematically reviewed using the …

Objective To develop new antiphospholipid syndrome (APS) classification criteria with high
specificity for use in observational studies and trials, jointly supported by the American …

The objective was to develop evidence-based recommendations for the management of
antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature …

Histiocytoses are rare disorders of unknown origin with highly heterogeneous prognosis.
BRAF mutations have been observed in Langerhans cell histiocytosis (LCH). We investigated …