CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of
central nervous system pain mechanisms (for example, loss of descending analgesic activity …

Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread
musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a …

Introduction Disease remission has become a feasible goal for most rheumatoid arthritis (RA)
patients; however, patient-reported symptoms, such as pain, may persist despite remission…

Pain is the most common reason patients with inflammatory arthritis see a rheumatologist.
Patients consistently rate pain as one of their highest priorities, and pain is the single most …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Objective To assess experimental pain sensitivity and compare the inflammatory response
to pain in 26 osteoarthritis (OA) patients and 33 age‐ and sex‐matched controls from the …

Introduction Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA)
patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, …

Objective Among rheumatoid arthritis (RA) patients, the intensity of pain may be out of proportion
to the severity of peripheral inflammation. This observation suggests that mechanisms …

High-dimensional single-cell analyses have improved the ability to resolve complex mixtures
of cells from human disease samples; however, identifying disease-associated cell types or …