Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial hyperplasia
and chronic inflammation, which lead to the progressive destruction of cartilage and bone in …

Objective To clarify the roles of hyaluronan (HA) in joint inflammation and the process of joint
destruction, using 4‐methylumbelliferone (4‐MU), an inhibitor of HA synthesis, in a mouse …

Background The aim of this study was to assess the effects of soluble sialic acid-binding
immunoglobulin-type lectin (sSiglec)-9 on joint inflammation and destruction in a murine …

This study aimed to evaluate the short-term effectiveness and safety profiles of baricitinib
and explore factors associated with improved short-term effectiveness in patients with …

Objective Whether the Boolean‐based American College of Rheumatology/European League
Against Rheumatism ( EULAR ) criteria for rheumatoid arthritis ( RA ) including patient‐…

Objectives The purpose of this study was to examine the treatment retention and efficacy of
abatacept, the first member of a new class of biologic agents, in Japanese rheumatoid …

Objective. Our study aimed to evaluate the longterm efficacy and safety of abatacept (ABA),
and to explore factors that increase its longterm efficacy in patients with rheumatoid arthritis (…

This observational retrospective study examined whether abatacept efficacy could be
augmented with concomitant methotrexate (MTX) or tacrolimus (TAC) in patients with rheumatoid …

Objective To determine the effects of concomitant methotrexate (MTX) on the incidence of
large joint replacement resulting from the progression of large joint destruction in patients with …

Favourable clinical results in rheumatoid arthritis (RA) patients with high disease activity (HDA)
are difficult to achieve. This study evaluated the clinical efficacy of abatacept according to …