[HTML][HTML] Decreased extra-renal urate excretion is a common cause of hyperuricemia
…, Y Shinohara, M Hosoyamada, Y Sakurai… - Nature …, 2012 - nature.com
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which
raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate '…
raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate '…
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population
…, K Kamakura, S Nonoyama, Y Sakurai… - Science translational …, 2009 - science.org
Gout based on hyperuricemia is a common disease with a genetic predisposition, which
causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on …
causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on …
[PDF][PDF] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia
…, Y Morimoto, K Kamakura, Y Sakurai… - The American Journal of …, 2008 - cell.com
Renal hypouricemia is an inherited disorder characterized by impaired renal urate (uric acid)
reabsorption and subsequent low serum urate levels, with severe complications such as …
reabsorption and subsequent low serum urate levels, with severe complications such as …
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes
…, K Inoue, Y Kato, Y Nakamura, Y Sakurai… - Annals of the …, 2016 - ard.bmj.com
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide
association studies (GWASs) of gout have been reported, they included self-reported gout …
association studies (GWASs) of gout have been reported, they included self-reported gout …
[HTML][HTML] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
…, H Nakagawa, T Ito, K Niwa, K Yamamoto, Y Sakurai… - Scientific reports, 2014 - nature.com
Gout is a common disease which results from hyperuricemia. We have reported that the
dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, …
dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, …
[HTML][HTML] Common dysfunctional variants in ABCG2 are a major cause of early-onset gout
…, A Mori, N Hamajima, H Suzuki, Y Kanai, Y Sakurai… - Scientific reports, 2013 - nature.com
Gout is a common disease which mostly occurs after middle age, but more people nowadays
develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, …
develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, …
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes
…, K Pavelka, LK Stamp, N Dalbeth, Y Sakurai… - Annals of the …, 2017 - ard.bmj.com
Objective A genome-wide association study (GWAS) of gout and its subtypes was performed
to identify novel gout loci, including those that are subtype-specific. Methods Putative …
to identify novel gout loci, including those that are subtype-specific. Methods Putative …
Regular physical activity and coronary risk factors in Japanese men
SD Hsieh, H Yoshinaga, T Muto, Y Sakurai - Circulation, 1998 - Am Heart Assoc
Background—Physical activity decreases the risk of coronary heart disease (CHD), but its
effects on risk factors require further exploration. Methods and Results—The study included …
effects on risk factors require further exploration. Methods and Results—The study included …
Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behcet's disease
S Ishikawa, M Taguchi, T Muraoka, Y Sakurai… - British Journal of …, 2014 - bjo.bmj.com
Aims To evaluate the efficacy of measuring subfoveal choroidal thickness in monitoring
uveitis activity before and after treatment with infliximab in patients with Behçet's disease (BD)-…
uveitis activity before and after treatment with infliximab in patients with Behçet's disease (BD)-…
[HTML][HTML] Elevated levels of cytokines associated with Th2 and Th17 cells in vitreous fluid of proliferative diabetic retinopathy patients
…, T Sato, A Tanaka, T Muraoka, M Taguchi, Y Sakurai… - PloS one, 2015 - journals.plos.org
Macrophages are involved in low-grade inflammation in diabetes, and play pathogenic roles
in proliferative diabetic retinopathy (PDR) by producing proinflammatory cytokines. T cells …
in proliferative diabetic retinopathy (PDR) by producing proinflammatory cytokines. T cells …