B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

…, M Fujimoto, T Matsushita, Y Matsushita… - The American journal of …, 2006 - Elsevier
Systemic sclerosis (scleroderma) is an autoimmune disease characterized by excessive
extracellular matrix deposition in the skin. A direct role for B lymphocytes in disease …

Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis.

T Matsushita, M Hasegawa, M Fujimoto… - The Journal of …, 2007 - jrheum.org
OBJECTIVE: To investigate the distribution of anti-aminoacyl-tRNA synthetase (anti-ARS)
antibodies among patients with autoimmune diseases, and to analyze the clinical features of …

[HTML][HTML] BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice

T Matsushita, M Fujimoto, M Hasegawa… - Journal of Investigative …, 2007 - Elsevier
The tight-skin (TSK/+) mouse, a genetic model for systemic sclerosis (SSc), develops
cutaneous fibrosis and autoimmunity. Although immunological abnormalities have been …

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1

…, Y Matsushita, T Fujita, T Matsushita… - Journal of Leucocyte …, 2007 - academic.oup.com
Skin wound healing is mediated by inflammatory cell infiltration that is highly regulated by
various adhesion molecules. Mice lacking intercellular adhesion molecule-1 (ICAM-1) delayed …

A novel inhibitor of Smad‐dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis

M Hasegawa, Y Matsushita, M Horikawa… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc),
and an increasing number of promising molecular targets for antifibrotic therapies have …

Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ‐specific autoimmune diseases

T Matsushita, M Hasegawa, Y Matsushita… - Experimental …, 2007 - Wiley Online Library
Serum levels of B‐cell activating factor belonging to the tumor necrosis factor family (BAFF),
a potent B‐cell survival factor, are elevated in patients with systemic autoimmune diseases, …

Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse

…, K Yanaba, T Matsushita, Y Matsushita… - Annals of the …, 2008 - ard.bmj.com
Objective : To assess the association of CD40/CD40 ligand (CD40L) interactions with the
development of skin fibrosis and autoimmunity in tight-skin (TSK/+) mouse, which is a mouse …

IgG4-related skin disease, a mimic of angiolymphoid hyperplasia with eosinophilia

Y Hamaguchi, M Fujimoto, Y Matsushita… - Dermatology, 2012 - karger.com
Mikulicz’s disease is considered one of the IgG4-related diseases that are characterized by
elevated serum IgG4 concentrations and the immunohistochemical finding of IgG4-positive …

L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury

…, T Fujita, Y Matsushita, T Matsushita… - Journal of leukocyte …, 2006 - academic.oup.com
Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis.
We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this …

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice

Y Matsushita, M Hasegawa, T Matsushita… - The Journal of …, 2007 - journals.aai.org
The tight-skin (TSK/+) mouse, a genetic model for systemic sclerosis, develops cutaneous
fibrosis. Although a fibrillin 1 gene mutation and immunological abnormalities have been …