Objective. To describe the longterm safety and efficacy profile of tofacitinib in patients with
moderate to severe active rheumatoid arthritis (RA). Methods. Data were pooled from 2 open-…

The mechanism of wound healing induced by topical application of an ointment containing
a new stable prostacyclin analogue, SM-10902 ((+)-methyl[2-[(2R,3aS,4R,5R,6aS)-octahydro-…

Prostaglandins E 1 , prostaglandin E 2 , 3-oxa-methano-prostaglandin I 1 (SM-10906), a
stable prostaglandin I 2 analog, and dibutyryl cyclic AMP suppressed the production of tumor …

SM-10661 [(+/-)-(cis)-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one HCl] displayed marked in
vitro inhibition of rabbit platelet aggregation induced by 1-O-alkyl-2-acetyl-sn-glycero-3-…

Intravenous infusion of endotoxin (0.25 mg/kg/hr for 4 hr) was shown to induce disseminated
intravascular coagulation (DIC) in rats, which resulted in hypofibrinogenemia, prolongation …

The mechanism of the antiplatelet functions of SM-10906, the active form of the 3-oxa-methano-prostaglandin
(PG) I1 analog SM-10902, was examined in rat platelets. SM-10906 …

A new stable prostacyclin analogue, pimilprost is a prodrug and rapidly converted by serum
esterase into its active form with vasodilating and anti-platelet activities. As pimilprost is …

Natronambulite from the Dohnoiri mine was found as the second occurrence in Japan. It is an
essential constituent of bedded manganese ores formed by very weak metamorphism. The …

Obesity is linked to a variety of metabolic disorders, such as insulin resistance and
atherosclerosis. Dysregulated production of fat-derived secretory factors, adipocytokines, is partly …

The oxidative phosphorylation (OXPHOS) system generates most of the ATP in respiring
cells. ATP-depleting conditions, such as hypoxia, trigger responses that promote ATP …