Peptide immunotherapy using multiple predominant allergen-specific T cell epitopes is a
safe and promising strategy for the control of type I allergy. In this study, we developed …

OBJECTIVE To investigate the incidence of retinopathy in systemic lupus erythematosus (SLE)
and to clarify its significance in relation to other clinical manifestations. METHODS A …

OBJECTIVE: To examine the frequency of depressive symptoms and also to identify factors
closely associated with their development in patients with scleroderma (systemic sclerosis, …

Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates interferon-induced
genes and type I interferons. Recently, studies of IRF-1-deficient mice have revealed that …

CD28 provides a critical costimulatory signal in Ag-specific T cell activation. Recent studies
have revealed an important role for CD28 in the development of autoimmune diseases. We …

MRL/Mpj-lpr/lpr (MRL/lpr) mice develop autoimmune disorders, including lymphoproliferation,
glomerulonephritis, autoantibody production, and hypergammaglobulinemia. To …

Objective Interferon regulatory factor 5 (IRF‐5) is a transcription factor that mediates intracellular
signals activated by engagement of Toll‐like receptors (TLRs). IRF5 polymorphisms are …

The incidence of herpes zoster was determined in patients with systemic lupus erythematosus
(SLE) and the cellular and humoral immunity to varicella zoster virus (VZV) investigated in …

TNF is a potent proinflammatory cytokine important for the development of arthritis in human
and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2 …

Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated
with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE …