The uric-5 gene is required for guiding pioneering axons and migrating ceils along the body
wail in C. eiegans. In mutants, dorsal migrations are disrupted, but ventral and longitudinal …

Vitiligo is an autoimmune disease of the skin that results in disfiguring white spots. There
are no US Food and Drug Administration–approved treatments for vitiligo, and most off-label …

OBJECTIVES: This study investigates issues associated with the United States Orphan Drug
Act. METHODS: A comprehensive orphan drug database was compiled from FDA data and …

We conducted a genome-wide association study of generalized vitiligo in the Chinese Han
population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs …

GROWTH cones in developing nervous systems encounter a sequence of extracellular cues
during migration 1,2 . In theory, a growth cone can navigate by selectively expressing or …

Purpose: The collagen triple helix repeat containing 1 (CTHRC1) is a promigratory protein
first found to be expressed during rat tissue repair process. Recent preliminary results …

CD47 is overexpressed in many human cancers, its level positively correlates with tumor
invasion and metastasis. However, it is largely unknown whether CD47 overexpression drives …

Melanoma is one of the most aggressive cancers affecting humans. Although early
melanomas are curable with surgical excision, metastatic melanomas are associated with high …

Purpose: Integrin-linked kinase (ILK), a key component of the extracellular matrix adhesion,
has been studied extensively in recent years. Overexpression of ILK in epithelial cells results …

Macrophages have key roles in tumor development and invasion in several human cancers,
but little is known about their pathogenic role in cutaneous T-cell lymphoma (CTCL). Herein, …