The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin

CD Sadik, Y Miyabe, T Sezin, AD Luster - Seminars in immunology, 2018 - Elsevier
The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …

[HTML][HTML] Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

…, J Shimizu, C Miyabe, K Yudo, Y Miyabe - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Chemokines in rheumatic diseases: pathogenic role and therapeutic implications

Y Miyabe, J Lian, C Miyabe, AD Luster - Nature Reviews Rheumatology, 2019 - nature.com
Chemokines, a family of small secreted chemotactic cytokines, and their G protein-coupled
seven transmembrane spanning receptors control the migratory patterns, positioning and …

[HTML][HTML] Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis

…, Y Miyabe, A Takayasu, S Fukuda, C Miyabe… - Arthritis research & …, 2011 - Springer
Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …

[PDF][PDF] Astrocyte-and neuron-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in viral encephalitis

BD Michael, L Bricio-Moreno, EW Sorensen, Y Miyabe… - Cell reports, 2020 - cell.com
Herpes simplex virus (HSV)-1 encephalitis has significant morbidity partly because of an
over-exuberant immune response characterized by leukocyte infiltration into the brain and …

[HTML][HTML] Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

…, W Yokoyama, C Miyabe, Y Miyabe… - BMC musculoskeletal …, 2014 - Springer
Background Some of cannabinoids, which are chemical compounds contained in marijuana,
are immunosuppressive. One of the receptors, CB receptor 1 (CB 1 ), is expressed …

An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy

C Miyabe, Y Miyabe, K Strle, ND Kim… - Annals of the …, 2017 - ard.bmj.com
Objectives Randomised-controlled trials have recently proven the efficacy of the interleukin (IL)-6
receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …

Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis

Y Miyabe, C Miyabe, TT Murooka, EY Kim… - Science …, 2017 - science.org
The deposition of immune complexes (ICs) in tissues induces a “type III hypersensitivity”
that results in tissue damage and underlies the pathogenesis of many autoimmune diseases. …

Pathogenic role of CXCR7 in rheumatoid arthritis

…, N Ohyanagi, K Kaneko, Y Miyabe… - Arthritis & …, 2010 - Wiley Online Library
Objective The interaction between CXCL12 and its receptor, CXCR4, in the synovium of
patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, …

Necessity of lysophosphatidic acid receptor 1 for development of arthritis

Y Miyabe, C Miyabe, Y Iwai, A Takayasu… - Arthritis & …, 2013 - Wiley Online Library
Objective Lysophosphatidic acid (LPA) is a bioactive lipid that binds to a group of cell surface
G protein–coupled receptors (LPA receptors 1–6 [LPA 1–6 ]) and has been implicated as …