The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin
The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …
[HTML][HTML] Chemokines and chemokine receptors as promising targets in rheumatoid arthritis
…, J Shimizu, C Miyabe, K Yudo, Y Miyabe - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …
Chemokines in rheumatic diseases: pathogenic role and therapeutic implications
Y Miyabe, J Lian, C Miyabe, AD Luster - Nature Reviews Rheumatology, 2019 - nature.com
Chemokines, a family of small secreted chemotactic cytokines, and their G protein-coupled
seven transmembrane spanning receptors control the migratory patterns, positioning and …
seven transmembrane spanning receptors control the migratory patterns, positioning and …
[HTML][HTML] Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
…, Y Miyabe, A Takayasu, S Fukuda, C Miyabe… - Arthritis research & …, 2011 - Springer
Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …
[PDF][PDF] Astrocyte-and neuron-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in viral encephalitis
BD Michael, L Bricio-Moreno, EW Sorensen, Y Miyabe… - Cell reports, 2020 - cell.com
Herpes simplex virus (HSV)-1 encephalitis has significant morbidity partly because of an
over-exuberant immune response characterized by leukocyte infiltration into the brain and …
over-exuberant immune response characterized by leukocyte infiltration into the brain and …
[HTML][HTML] Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
…, W Yokoyama, C Miyabe, Y Miyabe… - BMC musculoskeletal …, 2014 - Springer
Background Some of cannabinoids, which are chemical compounds contained in marijuana,
are immunosuppressive. One of the receptors, CB receptor 1 (CB 1 ), is expressed …
are immunosuppressive. One of the receptors, CB receptor 1 (CB 1 ), is expressed …
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy
C Miyabe, Y Miyabe, K Strle, ND Kim… - Annals of the …, 2017 - ard.bmj.com
Objectives Randomised-controlled trials have recently proven the efficacy of the interleukin (IL)-6
receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …
receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …
Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis
Y Miyabe, C Miyabe, TT Murooka, EY Kim… - Science …, 2017 - science.org
The deposition of immune complexes (ICs) in tissues induces a “type III hypersensitivity”
that results in tissue damage and underlies the pathogenesis of many autoimmune diseases. …
that results in tissue damage and underlies the pathogenesis of many autoimmune diseases. …
Pathogenic role of CXCR7 in rheumatoid arthritis
…, N Ohyanagi, K Kaneko, Y Miyabe… - Arthritis & …, 2010 - Wiley Online Library
Objective The interaction between CXCL12 and its receptor, CXCR4, in the synovium of
patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, …
patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, …
Necessity of lysophosphatidic acid receptor 1 for development of arthritis
Y Miyabe, C Miyabe, Y Iwai, A Takayasu… - Arthritis & …, 2013 - Wiley Online Library
Objective Lysophosphatidic acid (LPA) is a bioactive lipid that binds to a group of cell surface
G protein–coupled receptors (LPA receptors 1–6 [LPA 1–6 ]) and has been implicated as …
G protein–coupled receptors (LPA receptors 1–6 [LPA 1–6 ]) and has been implicated as …