The pharmacological profile and the acute and chronic aquaretic effects of OPC-41061, a
novel nonpeptide human arginine vasopressin (AVP) V 2 -receptor antagonist, were …

Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis,
cell differentiation, and regulation of the immune system. Expression of these genes is …

A number of new 4 (lH)-quinazolinones were synthesized and evaluated in the carrageenin-induced
paw edema test. Most of the compounds were obtained by the cyclization of the …

Rationale: Multilineage-differentiating stress enduring (Muse) cells, pluripotent marker stage-specific
embryonic antigen-3 + cells, are nontumorigenic endogenous pluripotent-like stem …

Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems,
payers, and regulators. However, no harmonized international consensus definitions of …

Some 2-(fluoromethyl) analogues of2-methyl-3-aryl-4 (3/f)-quinazolinones have been
synthesized and screened for CNS activities. It was shown that the 2-(fluoromethyl) analogues …

Echocardiographic examinations were performed in 60 professional bicyclists and control
subjects to determine the effects of exercise on left ventricular hypertrophy and function. The …

Background: Metformin is a popular antidiabetic agent that is also used to treat heart failure
patients with type 2 diabetes mellitus. Several reports suggest that metformin may also have …

We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in a rabbit
model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 …

Preclinical tests in animal models are key steps in early drug development. Consequently,
the International Society of Nephrology held a consensus meeting that connected experts in …