To the Editor: Assignment of structure and function to all genes and gene products (such as
proteins) of all organisms represents a major challenge in this postgenomic era. Here we …

… Haibo Yang conceived the idea for the Article. Hui Meng, Jiali Dai, Yang Zhang, Yang Xu
and Baogeng Liu … Yang Xu amended the manuscript and gave suggestions for data analysis. …

Background Prediction of 3-dimensional protein structures from amino acid sequences
represents one of the most important problems in computational structural biology. The …

The I-TASSER server ( http://zhanglab.ccmb.med.umich.edu/I-TASSER ) is an online resource
for automated protein structure prediction and structure-based function annotation. In I-…

We describe the identification and characterization of circular intronic long noncoding RNAs
in human cells, which accumulate owing to a failure in debranching. The formation of such …

Exon circularization has been identified from many loci in mammals, but the detailed
mechanism of its biogenesis has remained elusive. By using genome-wide approaches and …

Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human
transcriptome. However, the biological functions of these circRNAs remain largely unclear. …

Inflammasome is an intracellular signaling complex of the innate immune system. Activation
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …

Our previous work has shown that architectural and application shifts have resulted in modern
OLTP databases increasingly falling short of optimal performance [10]. In particular, the …

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,
no specific and effective drugs for treating this disease have been reported until today. …