Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness

T Kikuchi, JC Adams, Y Miyabe, E So… - Medical electron …, 2000 - Springer
In the mammalian cochlea, there are two independent gap junction systems, the epithelial
cell gap junction system and the connective tissue cell gap junction system. Thus far, four …

The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin

CD Sadik, Y Miyabe, T Sezin, AD Luster - Seminars in immunology, 2018 - Elsevier
The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …

How to detect eosinophil ETosis (EETosis) and extracellular traps

…, Y Miyabe, C Furutani, T Saga, Y Moritoki… - Allergology …, 2021 - jstage.jst.go.jp
Eosinophils are short-lived and comprise only a small population of circulating leukocytes;
however, they play surprisingly multifunctional roles in homeostasis and various diseases …

[HTML][HTML] Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis

…, Y Miyabe, A Takayasu, S Fukuda, C Miyabe… - Arthritis research & …, 2011 - Springer
Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …

[PDF][PDF] Astrocyte-and neuron-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in viral encephalitis

BD Michael, L Bricio-Moreno, EW Sorensen, Y Miyabe… - Cell reports, 2020 - cell.com
Herpes simplex virus (HSV)-1 encephalitis has significant morbidity partly because of an
over-exuberant immune response characterized by leukocyte infiltration into the brain and …

Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver

H Ohara, Y Miyabe, Y Deyashiki, K Matsuura… - Biochemical …, 1995 - Elsevier
In this study, we compared the enzymatic reduction of 10 drugs with a ketone group by
homogeneous carbonyl reductase, aldehyde reductase and three dihydrodiol dehydrogenases of …

Multi-institutional validation study of commercially available deformable image registration software for thoracic images

N Kadoya, Y Nakajima, M Saito, Y Miyabe… - International Journal of …, 2016 - Elsevier
Purpose To assess the accuracy of the commercially available deformable image registration
(DIR) software for thoracic images at multiple institutions. Methods and Materials Thoracic 4…

[HTML][HTML] Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Phycobiliproteins of Dulse Palmaria palmata

T Furuta, Y Miyabe, H Yasui, Y Kinoshita, H Kishimura - Marine drugs, 2016 - mdpi.com
We examined the inhibitory activity of angiotensin I converting enzyme (ACE) in protein
hydrolysates from dulse, Palmaria palmata. The proteins extracted from dulse were mainly …

[HTML][HTML] Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

…, W Yokoyama, C Miyabe, Y Miyabe… - BMC musculoskeletal …, 2014 - Springer
Background Some of cannabinoids, which are chemical compounds contained in marijuana,
are immunosuppressive. One of the receptors, CB receptor 1 (CB 1 ), is expressed …

Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis

Y Miyabe, C Miyabe, TT Murooka, EY Kim… - Science …, 2017 - science.org
The deposition of immune complexes (ICs) in tissues induces a “type III hypersensitivity”
that results in tissue damage and underlies the pathogenesis of many autoimmune diseases. …