[HTML][HTML] Machine learning in chemoinformatics and drug discovery
… Lo et al. developed the ShapeAlign program that combines 2D and 3D metrics based on
the Obabel PF2 fingerprint, shapes and pharmacophoric points for unsupervised 3D chemical …
the Obabel PF2 fingerprint, shapes and pharmacophoric points for unsupervised 3D chemical …
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
… -specific or disease-related cell-free DNA molecules, the first approaches to liquid biopsies
were based on the analysis of genetic variations between individuals [for example, the Y …
were based on the analysis of genetic variations between individuals [for example, the Y …
The death domain superfamily in intracellular signaling of apoptosis and inflammation
The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …
Presence of fetal DNA in maternal plasma and serum
YMD Lo, N Corbetta, PF Chamberlain, V Rai… - The lancet, 1997 - thelancet.com
… DNA from plasma, serum, and nucleated blood cells from 43 pregnant women underwent a
sensitive Y-PCR assay to detect circulating male fetal DNA from women bearing male fetuses…
sensitive Y-PCR assay to detect circulating male fetal DNA from women bearing male fetuses…
ZnO nanowire UV photodetectors with high internal gain
ZnO nanowire (NW) visible-blind UV photodetectors with internal photoconductive gain as
high as G ∼ 10 8 have been fabricated and characterized. The photoconduction mechanism …
high as G ∼ 10 8 have been fabricated and characterized. The photoconduction mechanism …
Theory and experiment on microstrip antennas
Y Lo, D Solomon, W Richards - IEEE transactions on Antennas …, 1979 - ieeexplore.ieee.org
A simple theory based on the cavity model is developed to analyze microstrip antennas.
Formulas for numerous canonical shapes are given. In general the theoretically predicted …
Formulas for numerous canonical shapes are given. In general the theoretically predicted …
Testing the number of components in a normal mixture
Y Lo, NR Mendell, DB Rubin - Biometrika, 2001 - academic.oup.com
We demonstrate that, under a theorem proposed by Vuong, the likelihood ratio statistic based
on the Kullback–Leibler information criterion of the null hypothesis that a random sample …
on the Kullback–Leibler information criterion of the null hypothesis that a random sample …
[PDF][PDF] Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis
YMD Lo, MSC Tein, TK Lau, CJ Haines… - The American Journal of …, 1998 - cell.com
We have developed a real-time quantitative PCR assay to measure the concentration of
fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high …
fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high …
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma
Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis.
Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus …
Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus …
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …