Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases,
including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (ie, “…

Many papers have reported that osteoclasts play an important role in the pathogenesis of
rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the …

IL-23, which is composed of p19 and p40 subunits, is a proinflammatory cytokine that contributes
to the formation and maintenance of Th17 cells in inflammatory autoimmune diseases. …

IL‐17 is a proinflammatory cytokine crucial for osteoclastic bone resorption in the presence
of osteoblasts or synoviocytes in rheumatoid arthritis. However, the role of IL‐17 in …

This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from
peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-…

The current study explored our hypothesis that IFN‐γ‐producing human T cells inhibit human
osteoclast formation. Activated T cells derived from human PBMC were divided into IFN‐γ‐…

The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of
ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular …

Background Bone destruction and osteoporosis are accelerated in chronic inflammatory
diseases, such as rheumatoid arthritis (RA) and periodontitis, in which many studies have …

Behcet’s disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic
course and unknown cause. The pathogenesis of BD has not been fully elucidated; however…

Raised serum alkaline phosphatase (ALP) activity in rheumatoid arthritis (RA) has been
reported, although its aetiology is not clear. In this paper we investigate whether synovial tissue …