Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas)
protein 9 system provides a robust and multiplexable genome editing tool, enabling …

Discogenic lower back pain (DLBP) is the most common type of chronic lower back pain (LBP),
accounting for 39% of cases, compared to 30% of cases due to disc herniation, and even …

Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a
high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, …

As an essential nutrient and trace element, selenium is required for living organisms and its
beneficial roles in human health have been well recognized. The role of selenium is mainly …

Colorectal cancer ( CRC ) is the second leading cause of cancer‐related deaths worldwide.
However, a biomarker for a sensitive and simple diagnostic test and highly effective target …

We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can
survive and increase the amount of proteoglycans in intervertebral discs. We used the rabbit …

Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still
incompletely understood. Although traditionally considered a thermogenic tissue, brown adipose …

Background/Aims: HOX transcript antisense RNA (HOTAIR) plays a vital role in carcinogenesis.
However, its functional and regulatory roles remain unclear. In this study, we aimed to …

Background As of June 1, 2020, coronavirus disease 2019 (COVID-19) has caused more
than 6,000,000 infected persons and 360,000 deaths globally. Previous studies revealed …

Twenty clinical symptoms and four radiological signs of different joints in patients with
Kashin-Beck disease (KBD) were studied in 2560 subjects from endemic and non-endemic areas …