User profiles for William D. Leslie

william leslie

professor of medicine, university of manitoba
Verified email at sbgh.mb.ca
Cited by 36573

[HTML][HTML] 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary

…, SM Kaiser, B Kvern, K Siminoski, WD Leslie - Cmaj, 2010 - Can Med Assoc
Since the publication of the Osteoporosis Canada guide-lines in 2002, there has been a
paradigm shift in the prevention and treatment of osteoporosis and fractures. 1, 2 The focus now …

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

…, JM Koh, P Kollia, BL Langdahl, WD Leslie… - Nature …, 2012 - nature.com
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Trabecular bone score: a noninvasive analytical method based upon the DXA image

BC Silva, WD Leslie, H Resch, O Lamy… - Journal of Bone and …, 2014 - academic.oup.com
The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from
the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. TBS is …

Interpretation and use of FRAX in clinical practice

…, G El-Hajj Fuleihan, H Johansson, WD Leslie… - Osteoporosis …, 2011 - Springer
The introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk
on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also …

A meta‐analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX

…, A Odén, NC Harvey, WD Leslie, D Hans… - Journal of bone and …, 2016 - academic.oup.com
Trabecular bone score (TBS) is a gray‐level textural index of bone microarchitecture derived
from lumbar spine dual‐energy X‐ray absorptiometry (DXA) images. TBS is a bone mineral …

Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study

…, AL Goertzen, MA Krieg, WD Leslie - Journal of Bone and …, 2011 - academic.oup.com
William D Leslie William D Leslie … Hans and MA Krieg were completely blind to the
clinical data until the analysis were finalized by WD Leslie. …

Use of proton pump inhibitors and risk of osteoporosis-related fractures

…, LM Lix, CJ Metge, HJ Prior, S Leung, WD Leslie - Cmaj, 2008 - Can Med Assoc
Background: The use of proton pump inhibitors has been associated with an increased risk
of hip fracture. We sought to further explore the relation between duration of exposure to …

A meta‐analysis of the association of fracture risk and body mass index in women

…, E Lau, WD Leslie, D Mellström… - Journal of bone and …, 2014 - academic.oup.com
Several recent studies suggest that obesity may be a risk factor for fracture. The aim of this
study was to investigate the association between body mass index (BMI) and future fracture …

AGA technical review on osteoporosis in gastrointestinal diseases

CN Bernstein, WD Leslie, MS Leboff - Gastroenterology, 2003 - Elsevier
Osteoporosis is increasingly recognized as a source of significant disability, an awareness
that has prompted clinicians to actively pursue the diagnosis among high-risk patients. …

Trends in hip fracture rates in Canada

WD Leslie, S O'Donnell, S Jean, C Lagacé, P Walsh… - Jama, 2009 - jamanetwork.com
Context Hip fractures are a public health concern because they are associated with
significant morbidity, excess mortality, and the majority of the costs directly attributable to …