Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

…, S Zhang, F Zhao, Y Li, W Chen, X Yi, W Zheng… - …, 2008 - academic.oup.com
Drug resistance during chemotherapy is the major obstacle to the successful treatment of
many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a …

[HTML][HTML] Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

…, Y Hou, X Meng, X Huang, E Rao, W Zheng… - Nature …, 2017 - nature.com
Radiotherapy induces and promotes innate and adaptive immunity in which host STING
plays an important role. However, radioresistance in irradiated tumors can also develop, …

High levels of Nrf2 determine chemoresistance in type II endometrial cancer

T Jiang, N Chen, F Zhao, XJ Wang, B Kong, W Zheng… - Cancer research, 2010 - AACR
Type II endometrial cancer, which mainly presents as serous and clear cell types, has
proved to be the most malignant and recurrent carcinoma among various female genital …

Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration

…, J Bugno, C Han, S Li, H Liang, Z Xu, W Zheng… - Nature …, 2022 - nature.com
The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to
poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a …

Low-grade endometrial stromal sarcoma: hormonal aspects☆

MC Chu, G Mor, C Lim, W Zheng, V Parkash… - Gynecologic …, 2003 - Elsevier
OBJECTIVE: The goal of this work was to determine whether exposure to estrogen following
treatment of low-grade endometrial stromal sarcomas affects clinical outcome. METHODS: …

Randomized trial of intravenous versus intraperitoneal chemotherapy plus bevacizumab in advanced ovarian carcinoma: an NRG oncology/gynecologic oncology …

…, K Fujiwara, DS Alberts, W Zheng… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE To evaluate the impact of two different intraperitoneal (IP) chemotherapy
regimens on progression-free survival (PFS) among women with newly diagnosed advanced …

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

Y Shi, W Zheng, K Yang, KG Harris, K Ni… - Journal of Experimental …, 2020 - rupress.org
Most studies focus on how intestinal microbiota influence cancer immunotherapy through
activating gut immunity. However, immunotherapies related to innate responses such as CD47 …

The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinoma

W Zheng, X Yi, O Fadare, SX Liang… - The American journal …, 2008 - journals.lww.com
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly
expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. The aim …

Follicle-stimulating hormone receptor is expressed in human ovarian surface epithelium and fallopian tube.

W Zheng, MS Magid, EE Kramer… - The American journal of …, 1996 - ncbi.nlm.nih.gov
The cellular expression of pituitary gonadotropin receptors in gonadal tissues is poorly defined
because of the lack of suitable reagents. In this study, we developed in situ hybridization …

[HTML][HTML] Tubal origin of 'ovarian'low-grade serous carcinoma

…, L Xiang, SK Chambers, O Fadare, B Kong, W Zheng - Modern Pathology, 2011 - Elsevier
Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from
ovarian epithelial inclusions, cystadenomas, and borderline tumors. The current study was …