[HTML][HTML] A marker for Stevens–Johnson syndrome
WH Chung, SI Hung, HS Hong, MS Hsih, LC Yang… - Nature, 2004 - nature.com
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening
reactions of the skin to particular types of medication 1 , 2 , 3 . Here we show that …
reactions of the skin to particular types of medication 1 , 2 , 3 . Here we show that …
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening
adverse drug reactions characterized by massive epidermal necrosis, in which the specific …
adverse drug reactions characterized by massive epidermal necrosis, in which the specific …
[HTML][HTML] Carbamazepine-induced toxic effects and HLA-B* 1502 screening in Taiwan
…, HT Liao, YH Lin, CH Chen, WH Chung… - … England Journal of …, 2011 - Mass Medical Soc
Background Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main
cause of the Stevens–Johnson syndrome (SJS) and its related disease, toxic epidermal …
cause of the Stevens–Johnson syndrome (SJS) and its related disease, toxic epidermal …
Genetic variants associated with phenytoin-related severe cutaneous adverse reactions
Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging
from maculopapular exanthema to severe cutaneous adverse reactions, which include …
from maculopapular exanthema to severe cutaneous adverse reactions, which include …
HLA-B* 5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
SI Hung, WH Chung, LB Liou, CC Chu… - Proceedings of the …, 2005 - National Acad Sciences
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent
cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity …
cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity …
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
SI Hung, WH Chung, SH Jee, WC Chen… - Pharmacogenetics …, 2006 - journals.lww.com
The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug
reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), …
reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), …
Common risk allele in aromatic antiepileptic-drug induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese
SI Hung, WH Chung, ZS Liu, CH Chen… - …, 2010 - Future Medicine
Aims: Compared with other categories of drugs, such as antibiotics and NSAIDs, antiepileptic
therapies are associated with a high incidence of Stevens–Johnson syndrome (SJS) and …
therapies are associated with a high incidence of Stevens–Johnson syndrome (SJS) and …
Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
CY Wei, WH Chung, HW Huang, YT Chen… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Increasing studies have revealed that HLA alleles are the major genetic
determinants of drug hypersensitivity; however, the underlying molecular mechanism remains …
determinants of drug hypersensitivity; however, the underlying molecular mechanism remains …
Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome
BACKGROUND: Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal
necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses …
necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses …
Cancer metastasis: Mechanisms of inhibition by melatonin
Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a
gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing …
gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing …