Objective In rheumatoid arthritis ( RA ), anti–citrullinated protein antibodies ( ACPA s) and
rheumatoid factor ( RF ) are commonly used to aid in the diagnosis. Although these …

Synthetic membranes are used in a number of diverse applications, such as filtration 1,2 ,
bioreactors 2,3 , tissue culture 4 , analytical devices including sensors 2,5 , and as supports for …

Objectives. To investigate changes in neutrophil count and occurrences of infection in RA
patients treated with the IL-6 receptor-α inhibitor tocilizumab (TCZ). Methods. Data were …

Recent studies have suggested that vitamin D may have other important biologic activities in
addition to its well-characterized role in the maintenance of calcium homeostasis. Discovery …

As well as being responsible for calcium metabolism, calcitriol, the most active member of
the vitamin D group, interacts extensively with the immune system. The role of calcitriol in the …

The steroid hormone, 1 alpha,25-dihydroxyvitamin D3 (calcitriol), has been shown to inhibit
T cell proliferation, primarily through inhibition of interleukin 2 (IL-2) production. In these …

Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation
complexes accumulate in cells subjected to environmental stress. SG‐associated proteins such …

Objectives This phase III study evaluated the efficacy and safety of rituximab plus methotrexate
(MTX) in patients with active rheumatoid arthritis (RA) who had an inadequate response …

Objectives Rituximab is an effective treatment in patients with established rheumatoid arthritis
(RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the …

Background Tofacitinib is an oral Janus kinase inhibitor that is under investigation for the
treatment of psoriatic arthritis. We evaluated tofacitinib in patients with active psoriatic arthritis …