… Drs Tromp and Ouwerkerk contributed equally to this work and are co-first authors… Wouter
Ouwerkerk … Drs Tromp and Ouwerkerk contributed equally to this work and are co-first authors. …

The present paper systematically reviews and compares existing prediction models in order
to establish the strongest variables, models, and model characteristics in patients with heart …

Introduction Despite clear guidelines recommendations, most patients with heart failure and
reduced ejection–fraction (HFrEF) do not attain guideline-recommended target doses. We …

Introduction From a prospective multicentre multicountry clinical trial, we developed and
validated risk models to predict prospective all‐cause mortality and hospitalizations because of …

Background : Information on the pathophysiological differences between heart failure with
reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF) …

Background Guideline-recommended doses of angiotensin-converting-enzyme (ACE) inhibitors
or angiotensin-receptor blockers (ARBs), and β blockers are similar for men and women …

Left atrial (LA) structure and function in heart failure with reduced (HFrEF) versus preserved
ejection fraction (HFpEF) is only established in small studies. Therefore, we conducted a …

Aims Inflammation is a central process in the pathophysiology of heart failure (HF), but trials
targeting tumour necrosis factor (TNF)‐α were largely unsuccessful. Interleukin (IL)‐6 is an …

Background Echocardiography is the diagnostic modality for assessing cardiac systolic and
diastolic function to diagnose and manage heart failure. However, manual interpretation of …

Background Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor
blockers (ARBs), β blockers, and mineralocorticoid receptor antagonists (MRAs) are of proven …