Background Oral contraceptives are rarely prescribed for women with systemic lupus
erythematosus, because of concern about potential negative side effects. In this double-blind, …

Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …

Background: There is concern that exogenous female hormones may worsen disease activity
in women with systemic lupus erythematosus (SLE). Objective: To evaluate the effect of …

Objective To assess the safety, tolerability, biologic activity, and efficacy of belimumab in
combination with standard of care therapy (SOC) in patients with active systemic lupus …

Objective To estimate the incidence and prevalence of systemic lupus erythematosus (SLE)
in a sociodemographically diverse southeastern Michigan source population of 2.4 million …

Objective To determine the association of plasma B lymphocyte stimulator (BLyS) levels,
immunosuppressive therapy, and other clinical parameters with disease activity in systemic …

Objective Cyclophosphamide (CYC) therapy for systemic lupus erythematosus (SLE), a
disease predominantly affecting women of childbearing age, causes an unacceptably high …

BACKGROUND: The pathogenic significance of antineutrophilic cytoplasmic antibodies (ANCA)
in Wegener’s granulomatosis is controversial. Their presence is influenced by the extent…

Background: Venous thrombotic events (VTEs) have been observed in Wegener granulomatosis,
but the incidence rate is not known. Objective: To measure the incidence of VTEs in …

Severe systemic lupus erythematosus affecting the kidney or central nervous system may
lead to organ failure or death despite treatment with high doses of corticosteroids. To evaluate …