Background Risedronate increases bone mineral density in elderly women, but whether it
prevents hip fracture is not known. Methods We studied 5445 women 70 to 79 years old who …

Background and Methods Osteoporosis is a recognized complication of corticosteroid
therapy. Whether it can be prevented is not known. We conducted a 12-month, randomized, …

Objective To evaluate the clinical response, safety, and tolerability of a single intraarticular
injection of anakinra in patients with symptomatic osteoarthritis (OA) of the knee. Methods …

Objective To compare the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2)
inhibitor, with those of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and placebo in …

Objective To determine the efficacy and safety of vitamin D 50,000 units/week and calcium
1,000 mg/day in the prevention of corticosteroid induced osteoporosis. Methods A minimized …

144 patients with severe rheumatoid arthritis from six centres were randomised to receive
oral cyclosporin or placebo for 6 months. The initial daily dose of cyclosporin was 2·5 mg/kg, …

In order to determine whether an association exists between antiphospholipid antibodies (APLA)
and thromboembolic events in patients with systemic lupus erythematosus (SLE), we …

Objective To determine the upper gastrointestinal (GI) tolerability of celecoxib, naproxen,
and placebo in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods An …

Objective. To evaluate the long-term safety of tacrolimus 3 mg/day in patients with rheumatoid
arthritis (RA). Methods. Patients with active RA who had discontinued all DMARDs for at …

Background The emergence of new therapies for the treatment of rheumatoid arthritis (RA),
the paucity of head-to-head studies, and the heterogeneous nature of responses to current …