Objective The 1987 American College of Rheumatology (ACR; formerly, the American
Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticized …

CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Objective. To compare the relative efficacy and tolerability of amitriptyline, cyclobenzaprine,
and placebo in the treatment of fibromyalgia, and to identify predictors of response to …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation …

Objective The American College of Rheumatology and the European League Against
Rheumatism have developed new classification criteria for rheumatoid arthritis (RA). The aim of …

Objective. The Canadian Rheumatology Association (CRA) has developed recommendations
for the pharmacological management of rheumatoid arthritis (RA) with traditional and …

Droplet-based single-cell RNA-seq has emerged as a powerful technique for massively parallel
cellular profiling. While this approach offers the exciting promise to deconvolute cellular …

Objectives To evaluate clinical remission with subcutaneous abatacept plus methotrexate (MTX)
and abatacept monotherapy at 12 months in patients with early rheumatoid arthritis (RA)…

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …