Warfarin is the most commonly used oral anticoagulant in sub‐Saharan Africa. Dosing is
challenging due to a narrow therapeutic index and high interindividual variability in dose …

… Kawai, Vivian K. a ; Stein, C. Michael a ; Perrien, Daniel S. … Kawai, MD, MPH, Division
of Clinical Pharmacology, Vanderbilt University School of Medicine, 2200 Pierce Ave, 560 …

Objective Gestational diabetes ( GDM ) is characterized by maternal glucose intolerance
that manifests during pregnancy. Because GDM resembles type 2 diabetes (T2 DM ), shared …

Objective Patients with rheumatoid arthritis (RA) have increased risk of atherosclerotic
cardiovascular disease that is underestimated by the Framingham Risk Score (FRS). We …

Elevated concentrations of inflammatory mediators are characteristic of autoimmune disease
accompanied by chronic or recurrent inflammation. We examined the hypothesis that …

Aim: To determine whether genetic variants associated with warfarin dose variability were
associated with increased risk of major bleeding during warfarin therapy. Materials & methods: …

Objective We tested the hypothesis that initiation of tumor necrosis factor α (TNFα) antagonists
reduced the risk of fractures compared to nonbiologic comparators in patients with …

Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic
predisposition to AI disease associates with WBC counts in populations expected to have low …

Background Antinuclear antibodies (ANA) are antibodies present in several autoimmune
disorders. However, a large proportion of the general population (20%) also have a positive test…

Polygenic variation unrelated to disease contributes to interindividual variation in baseline
white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated …