[HTML][HTML] Circulating microRNAs as novel biomarkers for bone diseases–complex signatures for multifactorial diseases?

M Hackl, U Heilmeier, S Weilner, J Grillari - Molecular and cellular …, 2016 - Elsevier
Biomarkers are essential tools in clinical research and practice. Useful biomarkers must
combine good measurability, validated association with biological processes or outcomes, and …

Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

…, G Joseph, MC Nevitt, N Singh, U Heilmeier… - Annals of the …, 2015 - ard.bmj.com
Objective To evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict
the onset of radiographic knee osteoarthritis (OA). Materials and methods We performed a …

Serum miRNA signatures are indicative of skeletal fractures in postmenopausal women with and without type 2 diabetes and influence osteogenic and adipogenic …

U Heilmeier, M Hackl, S Skalicky… - Journal of Bone and …, 2016 - academic.oup.com
Standard DXA measurements, including Fracture Risk Assessment Tool (FRAX) scores,
have shown limitations in assessing fracture risk in Type 2 Diabetes (T2D), underscoring the …

[HTML][HTML] Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the amount of weight loss: 48-month data …

…, GB Joseph, BJ Schwaiger, U Heilmeier… - Osteoarthritis and …, 2016 - Elsevier
Objective To investigate compositional cartilage changes measured with 3T MRI-based T2
values over 48 months in overweight and obese individuals with different degrees of weight …

Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X‐ray, and MRI: Data from the osteoarthritis initiative

…, BJ Schwaiger, JA Lynch, U Heilmeier… - Journal of Magnetic …, 2018 - Wiley Online Library
Background Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often
leads to severe disability. The rising rates of disability highlight the need for implementing …

[HTML][HTML] A reference database of cartilage 3 T MRI T2 values in knees without diagnostic evidence of cartilage degeneration: data from the osteoarthritis initiative

…, CE McCulloch, MC Nevitt, U Heilmeier… - Osteoarthritis and …, 2015 - Elsevier
Objective 1) To establish a gender- and BMI-specific reference database of cartilage T2 values,
and 2) to assess the associations between cartilage T2 values and gender, age, and BMI …

[HTML][HTML] Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative

J Neumann, FC Hofmann, U Heilmeier… - Osteoarthritis and …, 2018 - Elsevier
Purpose Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a
potential underlying relationship between both diseases. The purpose of this study was to …

In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC‐SL and conventional fast spin echo sequences at 1.5 and 3 T field strength

H Liebl, U Heilmeier, S Lee, L Nardo… - Journal of Magnetic …, 2015 - Wiley Online Library
Purpose To assess lesion detection and artifact size reduction of a multiacquisition variable‐resonance
image combination, slice encoding for metal artifact correction (MAVRIC‐SEMAC…

Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes …

U Heilmeier, M Hackl, F Schroeder, S Torabi, P Kapoor… - Bone, 2022 - Elsevier
Fragility fractures are an important hallmark of aging and an increasingly recognized
complication of Type 2 diabetes (T2D). T2D individuals have been found to exhibit an increased …

Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative

…, J Zarnowski, FC Hofmann, U Heilmeier… - Journal of Magnetic …, 2018 - Wiley Online Library
Purpose To investigate the association of the presence and severity of diabetes mellitus (DM)
with articular cartilage composition, using magnetic resonance imaging (MRI)‐based T 2 …