Interferon‐γ, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing
…, E Krüger, S Heink, U Kuckelkorn… - Immunological …, 2005 - Wiley Online Library
The proteasome system is a central component of a cascade of proteolytic processing steps
required to generate antigenic peptides presented at the cell surface to cytotoxic T …
required to generate antigenic peptides presented at the cell surface to cytotoxic T …
Peptide antigen production by the proteasome: complexity provides efficiency
M Groettrup, A Soza, U Kuckelkorn, PM Kloetzel - Immunology today, 1996 - Elsevier
Proteasomes have recently been shown to be central to the production of antigenic peptides
that can bind to major histocompatibility complex class I molecules. Here, Marcus Groettrup …
that can bind to major histocompatibility complex class I molecules. Here, Marcus Groettrup …
[HTML][HTML] Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress
…, N Lange, J Steffen, M Rieger, U Kuckelkorn… - Cell, 2010 - cell.com
Interferon (IFN)-induced immunoproteasomes (i-proteasomes) have been associated with
improved processing of major histocompatibility complex (MHC) class I antigens. Here, we …
improved processing of major histocompatibility complex (MHC) class I antigens. Here, we …
Comparative resistance of the 20S and 26S proteasome to oxidative stress
…, N SITTE, O ULLRICH, U KUCKELKORN… - Biochemical …, 1998 - portlandpress.com
Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome.
Concentrations of hydrogen peroxide (H 2 O 2 ) higher than 10 µmol/mg of protein are able …
Concentrations of hydrogen peroxide (H 2 O 2 ) higher than 10 µmol/mg of protein are able …
Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases.
K Egerer, U Kuckelkorn, PE Rudolph… - The Journal of …, 2002 - jrheum.org
… to therapy, and anti-dsDNA antibody titers measured by ELISA (reference value < 5.97 U/ml). …
Groettrup M, Soza A, Kuckelkorn U, Kloetzel PM. Peptide antigen production by the …
Groettrup M, Soza A, Kuckelkorn U, Kloetzel PM. Peptide antigen production by the …
Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
…, S Türkmen, I Zavrski, U Kuckelkorn, U Heider… - Blood, 2007 - ashpublications.org
… between the independent groups of healthy donors, patients with MGUS, and patients with
MM or between smoldering versus active MM were calculated by the Mann-Whitney U test. …
MM or between smoldering versus active MM were calculated by the Mann-Whitney U test. …
Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation
…, C Enenkel, A Voigt, U Kuckelkorn… - European Journal of …, 2014 - Wiley Online Library
… of the products by QME, we identified 105 peptides generated by T2 20S proteasomes from
the substrate pp89 16–40 , whereas only 14 peptides could be identified by Kuckelkorn and …
the substrate pp89 16–40 , whereas only 14 peptides could be identified by Kuckelkorn and …
The components of the proteasome system and their role in MHC class I antigen processing
By generating peptides from intracellular antigens which are then presented to T cells, the
ubiquitin/26S proteasome system plays a central role in the cellular immune response. The …
ubiquitin/26S proteasome system plays a central role in the cellular immune response. The …
[HTML][HTML] Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis
…, FL Heppner, U Völker, R Kandolf, U Kuckelkorn… - PLoS …, 2011 - journals.plos.org
… (C) Primary embryonic cardiomyocytes were stimulated with 100 U/ml IFN-γ for indicated
time points and the expression of 20S proteasome immunosubunits was determined in whole …
time points and the expression of 20S proteasome immunosubunits was determined in whole …
Incorporation of major histocompatibility complex–encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products …
U Kuckelkorn, S Frentzel, R Kraft… - European journal of …, 1995 - Wiley Online Library
The 20S proteasome is the enzyme complex responsible for the processing of antigens
bound by major histocompatibility complex class I molecules. The role of the interferon‐γ (IFN‐γ)‐…
bound by major histocompatibility complex class I molecules. The role of the interferon‐γ (IFN‐γ)‐…