Recent insights in rheumatoid arthritis (RA) necessitated updating the European League
Against Rheumatism (EULAR) RA management recommendations. A large international Task …

Objectives To provide an update of the European League Against Rheumatism (EULAR)
rheumatoid arthritis (RA) management recommendations to account for the most recent …

Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response,
inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in …

Innate immune responses are important in combating various microbes during the early
phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B …

Background Reaching the therapeutic target of remission or low-disease activity has
improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target …

AKARI, the first Japanese satellite dedicated to infrared astronomy, was launched on 2006
February 21, and started observations in May of the same year. AKARI has a 68.5 cm cooled …

Objective: To evaluate the ability of tocilizumab (a humanised anti-IL-6 receptor antibody)
monotherapy to inhibit progression of structural joint damage in patients with RA. Methods: In a …

In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for
antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway …

Objective To develop and validate revised classification criteria for granulomatosis with
polyangiitis (GPA). Methods Patients with vasculitis or comparator diseases were recruited into …

Objective To develop and validate revised classification criteria for eosinophilic granulomatosis
with polyangiitis (EGPA). Methods Patients with vasculitis or comparator diseases were …