Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular …

Activation of protein kinase C (PKC) is implicated as an important mechanism by which
diabetes causes vascular complications. We have recently shown that a PKC β inhibitor …

Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal
injury in patients with metabolic syndrome may be a result of altered renal lipid metabolism…

Metabolic syndrome has been reported to be associated with chronic kidney disease, but the
mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is …

To estimate the frequency of remission/regression of microalbuminuria and to identify
factors affecting such outcomes in Japanese patients with type 2 diabetes, we observed 216 …

SIRT1, a class III histone deacetylase, is considered a key regulator of cell survival and
apoptosis through its interaction with nuclear proteins. In this study, we have examined the …

The activation of protein kinase C (PKC) found in diabetic glomeruli and glomerular mesangial
cells cultured under high glucose conditions has been proposed to contribute to the …

Oxidative stress is implicated to play an important role in the development of diabetic vascular
complications, including diabetic nephropathy. It is unclear whether oxidative stress is …

Thiazolidinedione (TZD) compounds are widely used as oral hypoglycemic agents. Herein,
we provide evidence showing that troglitazone, one of the TZD compounds, is able to …

OBJECTIVE—Microalbuminuria in diabetic patients is a predictor for diabetic nephropathy
and cardiovascular disease. The aim of this study is to investigate the clinical impact of …