[PDF][PDF] Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus

…, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold… - Immunity, 2018 - cell.com
Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double
negative; DN). We show that DN cell expansions reflected a subset of CXCR5 - CD11c + …

[HTML][HTML] Transancestral mapping and genetic load in systemic lupus erythematosus

…, JF Moctezuma, SK Nath, TB Niewold… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

[HTML][HTML] MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

…, JH Ryu, EL Matteson, TB Niewold… - … England Journal of …, 2018 - Mass Medical Soc
Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

…, RP Kimberly, J Martin, JT Merrill, TB Niewold… - Nature …, 2011 - nature.com
Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized
by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, …

Association of the IRF5 risk haplotype with high serum interferon‐α activity in systemic lupus erythematosus patients

TB Niewold, JA Kelly, MH Flesch… - … : Official Journal of …, 2008 - Wiley Online Library
… erythematosus patients - Niewold - 2008 - Arthritis & Rheumatism - Wiley Online Library …
Niewold had full access to all of the data in the study and takes responsibility for the integrity …

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

LL Ritterhouse, SR Crowe, TB Niewold… - Annals of the …, 2011 - ard.bmj.com
Objectives Vitamin D deficiency is widespread and has been associated with many chronic
diseases, including autoimmune disorders. A study was undertaken to explore the impact of …

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

…, RR Goldman, LM Vila, JM Anaya, TB Niewold… - Genes & …, 2011 - nature.com
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex
pathogenesis in which genetic, hormonal and environmental factors have a role. Rare …

End‐Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1

…, SS Lim, JT Merrill, KL Sivils, TB Niewold… - Arthritis & …, 2014 - Wiley Online Library
Objective Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE)
that exhibits familial aggregation and may progress to end‐stage renal disease (ESRD). …

Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-α in lupus patients in vivo

…, L Barillas-Arias, MK Crow, TB Niewold - The Journal of …, 2009 - journals.aai.org
Increased IFN-α signaling is a primary pathogenic factor in systemic lupus erythematosus (SLE).
STAT4 is a transcription factor that is activated by IFN-α signaling, and genetic variation …

Network analysis of associations between serum interferon‐α activity, autoantibodies, and clinical features in systemic lupus erythematosus

…, M Jolly, JA James, JB Harley, TB Niewold - Arthritis & …, 2011 - Wiley Online Library
Objective Interferon‐α (IFNα) is a primary pathogenic factor in systemic lupus erythematosus
(SLE), and high IFNα levels may be associated with particular clinical manifestations. The …